The nutrient metabolism of patients with type 2 diabetes mellitus (T2DM) is closely linked to diabetes-related complications. Nutrient metabolism disorders, particularly those involving glucose, cholesterol, fatty acids, uric acid, amino acids, and vitamins metabolism, are not only associated with classic complications of diabetes (such as diabetic cerebrovascular disease, cardiovascular disease, nephropathy, retinopathy, and peripheral neuropathy), but also with potential diabetic outcomes like cognitive dysfunction, abnormal bone metabolism, metabolic fatty liver disease, and sarcopenia. Currently, there is extensive research on the relationship between nutrient metabolism and classic complications and comorbidities of diabetes. However, studies focusing on non-classical complications such as cognitive dysfunction, bone metabolism abnormalities, metabolic fatty liver disease, and sarcopenia are still scarce.

Therefore, there is an urgent need to delve into this under-researched area, specifically the relationship between nutrient metabolism and these non-classical complications. This relationship encompasses not only the occurrence of these complications but also their progression and key events, such as dementia, fractures, hospitalization, mortality, or the progression to advanced stages of disease, like the transition from metabolic fatty liver to metabolic steatohepatitis and even the development of hepatocellular carcinoma.

This Research Topic aims to explore the relationship between nutrient metabolism (including glucose, cholesterol, fatty acids, uric acid, amino acids, and vitamins metabolism) and diabetic complications including above mentioned classical complications and non-classical complications in various populations (e.g., different age and genders) from the perspective of clinical nutrition. Special attention will be given to the less commonly recognized non-classical complications in patients with T2DM. We hope that these studies will shed light on the key nutrient metabolism factors influencing patient outcomes and potentially lead to the development of appropriate intervention strategies in patients with T2DM.

We welcome submissions, including but not limited to the following aspects:
● The relationship between nutrient metabolism and cognitive impairment in patients with T2DM, particularly its connection to mild cognitive impairment and dementia, as well as the role of nutrient metabolism in the progression from mild cognitive impairment to dementia among patients with T2DM
● The relationship between nutrient metabolism and abnormal bone metabolism in patients with T2DM.
● The relationship between nutrient metabolism and metabolic fatty liver disease in patients with T2DM, particularly its connection to the transition from metabolic fatty liver to metabolic steatohepatitis and even the development of hepatocellular carcinoma.
● The relationship between nutrient metabolism and sarcopenia in patients with T2DM.
● Other classic complications of T2DM related to nutrient metabolism, not yet addressed in previous studies, represent an intriguing area of research

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Frontiers in Nutrition

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