Both cellular metabolism and tumor microenvironment (TME) have become hotspots in neuro-oncology, particularly in understanding and treating brain tumors such as glioblastoma, metastasis, etc. The metabolic reprogramming meets increased energy and biosynthetic demands of brain tumors, where they utilize glycolysis over oxidative phosphorylation for energy production, promoting rapid cell proliferation and survival of tumor cells in nutrient-deprived conditions. The emerging TME in brain tumors, including physical microenvironment, neuron-tumor interactions, immune cells, stromal cells and vasculature, significantly influences tumor progression and therapeutic response. However, the intricate metabolic interactions between tumor cells and TME are lack of sufficient understanding. In this special collection, we solicit papers focused on elucidating the interplay between metabolism and TME. We believe understanding this metabolism-TME nexus would holds promise for developing more effective therapeutic interventions and improving the outcomes of brain tumor patients.
Despite significant advancements in both fields of metabolism and the TME individually, our understanding of either how metabolic reprogramming in tumor cells influence TME, or how metabolic alteration in TME reciprocally interplays with tumor cells, remains limited. This shortage hampers the development of effective treatment tailored to unique metabolic needs and microenvironmental cues of brain tumors. In this research topic, we aim to tackle the problem that the complicated and poorly understood interplay between cellular metabolism and the TME in brain tumors. To achieve this, we advocate for a combination of cutting-edge research approaches in neuro-oncology, including high-throughput techniques in metabonomics, integrated multi-omics analysis, single-cell analysis, advanced bio-physics measurements, and mass cytometry on patient cohorts, as well as in vitro and in vivo models. We enthusiastically encourage submissions of papers presenting such primary resources and novel findings in this field.
The scope of this Research Topic encompasses the intricate interplay between cellular metabolism and the tumor microenvironment in neuro-oncology. Contributors are encouraged to address the following specific themes:
1. Metabolism and Physical Traits in Neuro-oncology: Studies on the relationship between metabolic alterations and physical microenvironment in brain tumors are greatly welcomed.
2. Metabolic reprogramming and immune microenvironment in brain cancers: Investigations on interplay between metabolic alterations and immune microenvironment changes in brain cancers are highly appreciated.
3. Neuron-tumor liaison and metabolism in cancer neuroscience: Researches on how metabolic alteration impacts neuron-tumor liaison or how electronic neuron-tumor network influences tumor metabolism are remarkably embraced.
4. Interplay between metabolism and tumor vasculature in brain tumors: Studies focused on the crosstalk between cellular metabolism and tumor vasculature, hypoxia or angiogenesis would be highly recommanded.
Types of manuscripts include:
1. Reviews: Comprehensive overviews of existing literatures on these themes.
2. Research Articles: Original experimental studies providing new insights into these topics.
3. Resource Papers: Papers offering new data sets, tools, or methods relevant to the study of the interplay between metabolism and TME in brain tumors.
4. Data Mining Researches: Studies employing data mining with solid experimental validations.
Overall, this Research Topic aims to bring together diverse studies that advance our understanding of the metabolic dynamics within the tumor microenvironment of brain cancers and identify novel therapeutic strategies.
Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.
Keywords:
Metabolic reprogramming, Neuro-oncology, Tumor microenvironment, Physical traits of tumor, Immune microenvironment, Neuron-tumor interaction, Tumor vasculature
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Both cellular metabolism and tumor microenvironment (TME) have become hotspots in neuro-oncology, particularly in understanding and treating brain tumors such as glioblastoma, metastasis, etc. The metabolic reprogramming meets increased energy and biosynthetic demands of brain tumors, where they utilize glycolysis over oxidative phosphorylation for energy production, promoting rapid cell proliferation and survival of tumor cells in nutrient-deprived conditions. The emerging TME in brain tumors, including physical microenvironment, neuron-tumor interactions, immune cells, stromal cells and vasculature, significantly influences tumor progression and therapeutic response. However, the intricate metabolic interactions between tumor cells and TME are lack of sufficient understanding. In this special collection, we solicit papers focused on elucidating the interplay between metabolism and TME. We believe understanding this metabolism-TME nexus would holds promise for developing more effective therapeutic interventions and improving the outcomes of brain tumor patients.
Despite significant advancements in both fields of metabolism and the TME individually, our understanding of either how metabolic reprogramming in tumor cells influence TME, or how metabolic alteration in TME reciprocally interplays with tumor cells, remains limited. This shortage hampers the development of effective treatment tailored to unique metabolic needs and microenvironmental cues of brain tumors. In this research topic, we aim to tackle the problem that the complicated and poorly understood interplay between cellular metabolism and the TME in brain tumors. To achieve this, we advocate for a combination of cutting-edge research approaches in neuro-oncology, including high-throughput techniques in metabonomics, integrated multi-omics analysis, single-cell analysis, advanced bio-physics measurements, and mass cytometry on patient cohorts, as well as in vitro and in vivo models. We enthusiastically encourage submissions of papers presenting such primary resources and novel findings in this field.
The scope of this Research Topic encompasses the intricate interplay between cellular metabolism and the tumor microenvironment in neuro-oncology. Contributors are encouraged to address the following specific themes:
1. Metabolism and Physical Traits in Neuro-oncology: Studies on the relationship between metabolic alterations and physical microenvironment in brain tumors are greatly welcomed.
2. Metabolic reprogramming and immune microenvironment in brain cancers: Investigations on interplay between metabolic alterations and immune microenvironment changes in brain cancers are highly appreciated.
3. Neuron-tumor liaison and metabolism in cancer neuroscience: Researches on how metabolic alteration impacts neuron-tumor liaison or how electronic neuron-tumor network influences tumor metabolism are remarkably embraced.
4. Interplay between metabolism and tumor vasculature in brain tumors: Studies focused on the crosstalk between cellular metabolism and tumor vasculature, hypoxia or angiogenesis would be highly recommanded.
Types of manuscripts include:
1. Reviews: Comprehensive overviews of existing literatures on these themes.
2. Research Articles: Original experimental studies providing new insights into these topics.
3. Resource Papers: Papers offering new data sets, tools, or methods relevant to the study of the interplay between metabolism and TME in brain tumors.
4. Data Mining Researches: Studies employing data mining with solid experimental validations.
Overall, this Research Topic aims to bring together diverse studies that advance our understanding of the metabolic dynamics within the tumor microenvironment of brain cancers and identify novel therapeutic strategies.
Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.
Keywords:
Metabolic reprogramming, Neuro-oncology, Tumor microenvironment, Physical traits of tumor, Immune microenvironment, Neuron-tumor interaction, Tumor vasculature
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.