Metabolism and Tumor Microenvironment Nexus in Neuro-Oncology

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About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 10 May 2025

  2. This Research Topic is still accepting articles.

    1. Check author guidelines

Background

In the field of neuro-oncology, the dual topics of cellular metabolism and the tumor microenvironment (TME) have gained significant traction, particularly when addressing brain tumors such as glioblastoma and metastasis. The link between metabolism and TME is fundamental to understanding the unique physiological demands of tumors, as brain tumors primarily utilize glycolysis, bypassing oxidative phosphorylation, to support high rates of cell proliferation and survival in nutrient-poor conditions. Despite the recognized importance of metabolic reprogramming and TME interactions in tumor progression and therapy responses, the complex metabolic pathways and their interrelations within the TME remain insufficiently understood, posing significant research and clinical challenges.

This Research Topic aims to shed light on the complex interplay between cellular metabolism and the TME in the management and treatment of brain tumors. By focusing on how metabolic reprogramming influences the TME and, conversely, how alterations in the TME affect tumor metabolism, we seek to fill the current knowledge gap and potentially uncover novel therapeutic targets. We encourage the submission of studies employing advanced research methodologies, such as high-throughput metabonomics, multi-omics integration, single-cell analysis, biophysical measurements, and mass cytometry, which can provide groundbreaking insights into these interactions.

To further clarify this intricate relationship, our Research Topic encompasses a range of specific sub-themes within neuro-oncology:
o Metabolism and Physical Traits in Neuro-oncology: Exploring how metabolic changes correlate with the physical aspects of brain tumors.
o Metabolic Reprogramming and the Immune Microenvironment: Investigating the effects of metabolic changes on immunological landscapes in brain cancer.
o Neuron-Tumor Liaison and Metabolism: Delving into the metabolic factors influencing neuron-tumor interactions.
o Interactions of Metabolism with Tumor Vasculature: Studying the connections between metabolic pathways and vascular structures in brain tumors.

Through this Research Topic, we aim to converge various studies that forward our understanding of metabolic and environmental dynamics within brain tumors, thereby paving the way for innovative therapeutic approaches.

Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.

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This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

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  • Editorial
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  • Hypothesis and Theory
  • Methods
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Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion
  • Original Research
  • Perspective
  • Review
  • Study Protocol
  • Systematic Review
  • Technology and Code

Keywords: Metabolic reprogramming, Neuro-oncology, Tumor microenvironment, Physical traits of tumor, Immune microenvironment, Neuron-tumor interaction, Tumor vasculature

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

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