The liver is a very complex organ that performs several vital functions, many of which cannot yet be replaced by the most advanced therapeutic technologies. Liver health and nutrition are closely linked, and the relationship between dietary intake and liver disease has been studied in recent years. Despite its importance in the development and severity of many medical problems, not enough attention has been paid to nutrition. Nutrition plays an important role not only in the etiology but also in the pathogenesis of liver diseases. While an extreme nutritional state (malnutrition or obesity) can lead to liver dysfunction, a dysfunctional liver can lead to changes in the metabolism of macro- and micronutrients. Animal and human evidence support the harmful effects of consuming higher fat, high-carbohydrate diets, which can lead to liver dysfunction that affects overall health. Conversely, nutritional therapy plays an important role in the treatment of liver disease.

It is well known that chronic liver diseases, especially liver cirrhosis, can contribute to malnutrition. On the other hand, malnutrition has been identified as a contributing factor to the progression of these liver diseases. Based on this, the aim of this special issue is to explore some of the scenarios between nutrition and liver health and disease in preclinical or clinical approaches.

We welcome original research articles (including basic science, human and animal studies) that address the impact of dietary habits on liver health and disease. We encourage submissions that highlight the interface between diet and microcirculation, a recognized significant mediator of chronic liver disease. We welcome submissions of original research articles, review articles, mini-reviews, narrative and systematic reviews, and meta-analyzes and case reports related to, but not limited to, the following subtopics:

• Interdisciplinary and translational research and clinical application of nutritional interventions
• The contribution of nutrition to tissue/organ homeostasis
• The interrelationship between genetic factors and nutrition
• Dietary patterns and dysbiosis
• Changes in microcirculatory blood flow
• Endothelial function and damage
• Dietary interventions targeting the conditions described above
• Multi-omics based methods for the diagnosis and management of nutritional status
• New techniques and advances in technology to shed light on the role of dietary habits in liver health and disease

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Frontiers in Nutrition

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