Cancer is a disease in which some of the body’s cells grow uncontrollably and spread to other parts of the body, causing millions of deaths worldwide every year. Surgical resection, chemoradiotherapy, targeted therapy and immunotherapy are the common strategies for cancer treatment. However, cancer is a heterogeneous disease with complex mechanisms, drug-resistance, recurrence and metastasis are the major challenges in cancer therapy. Precision oncology allows targeted therapy based on a person’s molecular and genetic characteristics. New and specific biomarkers are key to cancer precision diagnosis and treatment. The future of cancer care may well be one where a patient’s genetic profile is a standard part of oncology care, driving how we approach the detection, diagnosis, treatment, and outcomes of cancer patients around the world.
Natural compounds are a key source of compounds for drug discovery, as they tend to have favorable physicochemical properties and lower toxicity. Natural compounds such as flavonoids and polyphenols are abundant in food and plants, and have been demonstrated to have anti-cancer properties. Hence, the diversity of compounds in natural compounds is a library of interest to explore for their anti-cancer effect in precision oncology.
In this Research Topic, original articles, brief research reports, reviews, mini reviews, opinions, and perspectives are welcomed, which will include (but are not limited to):
1. Insights into the effect and mechanisms of natural compounds and their bioactive compounds on cancer cells in vitro and in vivo.
2. Use of novel nano-structured systems to standardize and potentiate the effects of natural compounds on cancer cells.
3. Identification of potential targets and molecular mechanisms under the treatment of natural compounds on cancer cells.
4. Novel links between natural compounds and metabolic pathways.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
Keywords:
precision oncology, biomarkers, natural compounds, combined treatment, high-throughput omics
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Cancer is a disease in which some of the body’s cells grow uncontrollably and spread to other parts of the body, causing millions of deaths worldwide every year. Surgical resection, chemoradiotherapy, targeted therapy and immunotherapy are the common strategies for cancer treatment. However, cancer is a heterogeneous disease with complex mechanisms, drug-resistance, recurrence and metastasis are the major challenges in cancer therapy. Precision oncology allows targeted therapy based on a person’s molecular and genetic characteristics. New and specific biomarkers are key to cancer precision diagnosis and treatment. The future of cancer care may well be one where a patient’s genetic profile is a standard part of oncology care, driving how we approach the detection, diagnosis, treatment, and outcomes of cancer patients around the world.
Natural compounds are a key source of compounds for drug discovery, as they tend to have favorable physicochemical properties and lower toxicity. Natural compounds such as flavonoids and polyphenols are abundant in food and plants, and have been demonstrated to have anti-cancer properties. Hence, the diversity of compounds in natural compounds is a library of interest to explore for their anti-cancer effect in precision oncology.
In this Research Topic, original articles, brief research reports, reviews, mini reviews, opinions, and perspectives are welcomed, which will include (but are not limited to):
1. Insights into the effect and mechanisms of natural compounds and their bioactive compounds on cancer cells in vitro and in vivo.
2. Use of novel nano-structured systems to standardize and potentiate the effects of natural compounds on cancer cells.
3. Identification of potential targets and molecular mechanisms under the treatment of natural compounds on cancer cells.
4. Novel links between natural compounds and metabolic pathways.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
Keywords:
precision oncology, biomarkers, natural compounds, combined treatment, high-throughput omics
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.