Protein post-translational modification (PTM) is an important process that involves the attachment and modification of small proteins, carbohydrates/lipids, or chemical substrates to proteins. PTM mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation, glycosylation, and ADP-ribosylation. It has a substantial impact on protein function, including enzyme activation and inactivation, protein stability, subcellular localization, and interactions. PTM possesses a pivotal role in regulating a wide range of physiopathologic functions in normal and cancer conditions. In particular, PTM is involved in multiple aspects of cancer progression, including the regulation of inflammation and immune response, metastatic formation, metabolic remodeling, and cancer susceptibility. Therefore, there is an increasing focus on the role of PTM in tumor progression.
This Research Topic aims to cover the latest advances in the evolving roles of PTM in remodeling cancer, as well as associated diagnostic and therapeutic applications. The potential subtopics include, but are not limited to:
1) The dynamic and spatio-temporal alteration of PTM characteristics within tumor progression;
2) The mechanisms of PTM involved in regulating tumor progression, including proliferation, invasion, metastasis, and therapeutic resistance;
3) The impact of PTM in modulating cancer immune;
4) Comprehensive PTM-based multi-omics bioinformatics analysis for constructing risk prediction and information prediction models for tumors;
5) Multiple therapeutic strategies for PTM-based tumors, including small molecule drug development for application, immunotherapy, targeted therapy, and nanotherapy.
Please note that manuscripts consisting solely of bioinformatics, mendelian randomization, computational analysis, or predictions of public databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted.
Keywords:
cancers, PTM, tumor progression, immune regulation, diagnosis, cancer therapy
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Protein post-translational modification (PTM) is an important process that involves the attachment and modification of small proteins, carbohydrates/lipids, or chemical substrates to proteins. PTM mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation, glycosylation, and ADP-ribosylation. It has a substantial impact on protein function, including enzyme activation and inactivation, protein stability, subcellular localization, and interactions. PTM possesses a pivotal role in regulating a wide range of physiopathologic functions in normal and cancer conditions. In particular, PTM is involved in multiple aspects of cancer progression, including the regulation of inflammation and immune response, metastatic formation, metabolic remodeling, and cancer susceptibility. Therefore, there is an increasing focus on the role of PTM in tumor progression.
This Research Topic aims to cover the latest advances in the evolving roles of PTM in remodeling cancer, as well as associated diagnostic and therapeutic applications. The potential subtopics include, but are not limited to:
1) The dynamic and spatio-temporal alteration of PTM characteristics within tumor progression;
2) The mechanisms of PTM involved in regulating tumor progression, including proliferation, invasion, metastasis, and therapeutic resistance;
3) The impact of PTM in modulating cancer immune;
4) Comprehensive PTM-based multi-omics bioinformatics analysis for constructing risk prediction and information prediction models for tumors;
5) Multiple therapeutic strategies for PTM-based tumors, including small molecule drug development for application, immunotherapy, targeted therapy, and nanotherapy.
Please note that manuscripts consisting solely of bioinformatics, mendelian randomization, computational analysis, or predictions of public databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted.
Keywords:
cancers, PTM, tumor progression, immune regulation, diagnosis, cancer therapy
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.