About this Research Topic
Protein post-translational modification (PTM) is a critical area of research that delves into the biochemical processes altering protein function through the attachment of small proteins, carbohydrates, lipids, or chemical substrates. PTMs such as methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation, glycosylation, and ADP-ribosylation significantly influence protein activity, stability, localization, and interactions. In the context of cancer, PTMs are integral to the regulation of inflammation, immune responses, metastasis, metabolic changes, and cancer susceptibility. Despite the growing body of evidence highlighting the importance of PTMs in cancer progression, there remain substantial gaps in understanding the precise mechanisms and potential therapeutic applications. Recent studies have begun to unravel the complex roles of PTMs in tumor biology, yet comprehensive insights into their dynamic and spatial-temporal characteristics are still lacking. Addressing these gaps is crucial for advancing diagnostic and therapeutic strategies in oncology.
This research topic aims to explore the latest advancements in understanding the roles of PTMs in cancer remodeling and their potential applications in diagnostics and therapy. The primary objectives include elucidating the dynamic alterations of PTMs during tumor progression, understanding the mechanisms by which PTMs regulate cancer processes such as proliferation, invasion, and metastasis, and investigating the impact of PTMs on cancer immunity. Additionally, the research seeks to develop PTM-based multi-omics bioinformatics models for risk prediction and explore novel therapeutic strategies targeting PTMs.
To gather further insights into the evolving roles of PTMs in cancer, we welcome articles addressing, but not limited to, the following themes:
- Dynamic and spatio-temporal alterations of PTM characteristics within tumor progression.
- Mechanisms of PTM in regulating tumor progression, including proliferation, invasion, metastasis, and therapeutic resistance.
- Impact of PTM in modulating cancer immune responses.
- Comprehensive PTM-based multi-omics bioinformatics analysis for constructing risk prediction models.
- Development of therapeutic strategies for PTM-based tumors, including small molecule drugs, immunotherapy, targeted therapy, and nanotherapy.
This research topic aims to explore the latest advancements in understanding the roles of PTMs in cancer remodeling and their potential applications in diagnostics and therapy. The primary objectives include elucidating the dynamic alterations of PTMs during tumor progression, understanding the mechanisms by which PTMs regulate cancer processes such as proliferation, invasion, and metastasis, and investigating the impact of PTMs on cancer immunity. Additionally, the research seeks to develop PTM-based multi-omics bioinformatics models for risk prediction and explore novel therapeutic strategies targeting PTMs.
To gather further insights into the evolving roles of PTMs in cancer, we welcome articles addressing, but not limited to, the following themes:
- Dynamic and spatio-temporal alterations of PTM characteristics within tumor progression.
- Mechanisms of PTM in regulating tumor progression, including proliferation, invasion, metastasis, and therapeutic resistance.
- Impact of PTM in modulating cancer immune responses.
- Comprehensive PTM-based multi-omics bioinformatics analysis for constructing risk prediction models.
- Development of therapeutic strategies for PTM-based tumors, including small molecule drugs, immunotherapy, targeted therapy, and nanotherapy.
Keywords: cancers, PTM, tumor progression, immune regulation, diagnosis, cancer therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
