Regulated cell death (RCD) is a precisely controlled cell death process that plays a crucial role in human physiology and pathophysiology. In the musculoskeletal system, RCD also holds a significant role. Firstly, RCD plays a critical role in musculoskeletal development and homeostasis by removing excess or unnecessary cells. Additionally, with aging and changes in the environment, the balance of RCD may be disrupted, leading to increased cell death and decreased cell function. In the musculoskeletal system, this imbalance can result in musculoskeletal disorders or diseases, such as intervertebral disc degeneration, osteoporosis, and osteoarthritis. Over the last two decades, distinct modes and concepts of RCD have been proposed, including PANoptosis, oxeiptosis, alkaliptosis, necroptosis, ferroptosis, cuproptosis and et al. Because of the dedicated but controllable molecular machinery involved in RCD, studying the role and mechanism of RCD in musculoskeletal development, homeostasis, and diseases, can accelerate the development of preventative and therapeutic targets.
Our goal is to bring together experts in the field of musculoskeletal biology, cell death regulation, and pathogenesis of musculoskeletal diseases to explore the role and mechanism of regulated cell death in musculoskeletal development, homeostasis, and diseases. By providing a comprehensive understanding of these complex processes, we aim to advance our understanding of musculoskeletal health and disease pathogenesis, and to identify new therapeutic targets and strategies for treating musculoskeletal diseases. It is worth noting that we welcome submissions that include but are not limited to Original Basic Research, Review and Bioinformatics Analysis.
We are interested in Original Basic Research, Review, Bioinformatics Analysis and et al., focusing on either of the following research topics:
1. Regulated cell death in the development of bone, cartilage and intervertebral disc;
2. Regulated cell death in osteoarthritis (OA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS);
3. Regulated cell death in intervertebral disc degeneration (IDD) and spinal cord injury (SCI);
4. Regulated cell death in bone tumors, scoliosis, and osteoporosis (OP);
5. Novel forms of regulated cell death in musculoskeletal health and diseases.
Keywords:
Regulated Cell Death, Bone, Cartilage, Intervertebral disc, Pyroptosis, Necroptosis, Ferroptosis, Alkaliptosis, Oxeiptosis, PANoptosis, Cuproptosis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Regulated cell death (RCD) is a precisely controlled cell death process that plays a crucial role in human physiology and pathophysiology. In the musculoskeletal system, RCD also holds a significant role. Firstly, RCD plays a critical role in musculoskeletal development and homeostasis by removing excess or unnecessary cells. Additionally, with aging and changes in the environment, the balance of RCD may be disrupted, leading to increased cell death and decreased cell function. In the musculoskeletal system, this imbalance can result in musculoskeletal disorders or diseases, such as intervertebral disc degeneration, osteoporosis, and osteoarthritis. Over the last two decades, distinct modes and concepts of RCD have been proposed, including PANoptosis, oxeiptosis, alkaliptosis, necroptosis, ferroptosis, cuproptosis and et al. Because of the dedicated but controllable molecular machinery involved in RCD, studying the role and mechanism of RCD in musculoskeletal development, homeostasis, and diseases, can accelerate the development of preventative and therapeutic targets.
Our goal is to bring together experts in the field of musculoskeletal biology, cell death regulation, and pathogenesis of musculoskeletal diseases to explore the role and mechanism of regulated cell death in musculoskeletal development, homeostasis, and diseases. By providing a comprehensive understanding of these complex processes, we aim to advance our understanding of musculoskeletal health and disease pathogenesis, and to identify new therapeutic targets and strategies for treating musculoskeletal diseases. It is worth noting that we welcome submissions that include but are not limited to Original Basic Research, Review and Bioinformatics Analysis.
We are interested in Original Basic Research, Review, Bioinformatics Analysis and et al., focusing on either of the following research topics:
1. Regulated cell death in the development of bone, cartilage and intervertebral disc;
2. Regulated cell death in osteoarthritis (OA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS);
3. Regulated cell death in intervertebral disc degeneration (IDD) and spinal cord injury (SCI);
4. Regulated cell death in bone tumors, scoliosis, and osteoporosis (OP);
5. Novel forms of regulated cell death in musculoskeletal health and diseases.
Keywords:
Regulated Cell Death, Bone, Cartilage, Intervertebral disc, Pyroptosis, Necroptosis, Ferroptosis, Alkaliptosis, Oxeiptosis, PANoptosis, Cuproptosis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.