Environmental-related diseases are rapidly growing due to the disarray of urbanization, industrialization, and climate change, bringing unprecedented challenges to human living worldwide. Various degrees of soil, air, water, and food contaminants/pollutants are known, even at low levels, to jeopardize normal human development and aging. In addition, environmental and natural disasters are gaining more attention as they widespread contaminants to local communities, increasing the risk for ill conditions, especially to more vulnerable populations. A better understanding of these effects is most needed to successfully build nutritional interventions for prevention and treatment strategies to ameliorate/halt their short and long-term deleterious consequences to human health.

This research topic is thematic on the role of nutritional factors affecting environmental-related diseases due to "unhealthy" exposome across the lifespan, including human exposure to heavy metals (including mercury, arsenic, lead etc.), air and water pollutants, early-life enteric pathogens, and chemicals such as benzene, polyfluoroalkyl (PFAS) substances, bisphenol A, etc. Such environmental challenges may lead to short and long-term neuroendocrine, gut-brain axis, cardiovascular disturbances, and growing casuistic of blood and other types of cancer, overall leading to worrisome public health issues and increased disability-adjusted life years scores, morbimortality, and high hospital costs. Interventions studies, including customized nutritional-related diets (e.g., fasting-mimicking diets), micronutrients, pre, and probiotics, as preventive and treatment-adjuvant measures, are welcome to reduce/ameliorate the pathophysiology of this escalating health problem worldwide.

This Research Topic aims to highlight advances in the understanding of the mechanisms and pathophysiological processes involved in the complex relationships between nutrition and environmental-borne diseases and potential ways for their amelioration. We welcome the submission of Original Research, Review, and Mini-Review articles on the following sub-topics:

- Interactions of nutrients, prebiotics/probiotics, environmental toxicants (eg. heavy metals, air pollutants, pesticides etc.) and their potential beneficial effect on human health
- The contribution of genomics, metagenomics, genetic and epigenetic factors as risk contributors or targets to nutritional interventions and diets to ameliorate environmental-borne diseases.
- Cause and consequences of early-life nutritional stressors to environmental-related diseases and their impact to long-term healthy aging.
- Interactions of nutritional factors and environmental hazards on cardiovascular, neurological, and neuroendocrine outcomes.
- Nutritional factors on environmental enteropathy and long-term consequences for child development, including gut-brain, gut-liver, and gut-bone axes with intestinal microbiota dysbiosis and intestinal inflammation.
- Nutritional factors and interventions on environmental-related blood cancer risk and outcomes, including interactions on genotoxic/DNA repair gene and transcriptional effects.

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Frontiers in Nutrition

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