Intestinal models for nutrition research have become increasingly significant in recent years, offering innovative ways to study nutrient digestion, absorption, and metabolism. Traditional methods often fall short in replicating the complex physiological and biochemical conditions of the human intestine. Artificial intestine and organ-on-chip models have emerged as powerful tools to bridge this gap. These models simulate the intricate processes of the human digestive system, including enzyme secretion and nutrient absorption, providing a more accurate and controlled environment for research. Despite their potential, there remain gaps in understanding how these models can fully replicate the human intestinal environment, particularly in the context of diet, drugs, and disease. Recent studies have shown promising results, yet the need for more comprehensive and integrated approaches persists. Addressing these gaps could lead to significant advancements in nutrient science and the development of new treatments and therapies.

This Research Topic aims to explore the role of intestinal models in nutrient science, focusing on their application in clinical research and their potential to simulate organism-level interactions. Key questions include the effectiveness of nutrient conversion and absorption models and the adequacy of organ-on-chip models for comprehensive studies. By investigating these areas, the research seeks to validate and enhance the use of artificial intestine simulators, organ-on-chip, and in silico models, ultimately contributing to a deeper understanding of nutrient metabolism and absorption.

To gather further insights into the capabilities and limitations of these models, we welcome articles addressing, but not limited to, the following themes:
- Development and validation of artificial intestine models
- Comparative studies of nutrient absorption models using host cell lines and tissues
- Integration of microbiota in nutrient metabolism models
- Applications of organ-on-chip models in nutrient research
- Impact of diet, drugs, and disease on intestinal models
- Ethical considerations and experimental design improvements in nutrient research
- Advances in in silico modeling for nutrient absorption and metabolism

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Frontiers in Nutrition

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