Metabolic syndrome is a global health problem, which is defined by WHO as a pathologic condition characterized by obesity, diabetes, hypertension, and hyperlipidemia. About 20-30% of adults were threatened by metabolic syndrome worldwide. Besides genetic factors, environmental factors, including dietary component intake, are one of the main causes of metabolic syndrome. Studies have shown that natural polyphenols from fruits, vegetables, and flowers effectively control or prevent metabolic diseases (e.g., obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver diseases) by multiple mechanism pathways, including anti-inflammation, regulating lipid metabolism, regulating gut bacteria and immune cell function. It is important to explore and identify the new polyphenols from natural resources. Meanwhile, bioactivities of polyphenols on preventing or controlling metabolic syndrome-associated diseases and potential mechanisms should be more studied to clarify the benefits of polyphenols. All the information will provide a theoretical basis for developing polyphenol-related functional products to improve human health.

This Research Topic aims to provide the latest research information about polyphenols from natural resources on metabolic syndrome regulation. Research on exploring polyphenols from new dietary resources, such as isolation, structural identification, structural changes during processing and structure-activity relationship, by novel techniques, is one of our interests. Studies on the improvement of absorption efficacy by drug delivery techniques provide ideas for polyphenol-related product development. It also contributes knowledge about the bioactivities and potential mechanisms of natural polyphenols on metabolic syndrome, providing the theoretical basis for prevention or treatment of metabolic syndrome-associated diseases, such as obesity, type 2 diabetes, hyperlipidemia and heart diseases.

This Topic welcomes high-quality research including Original Research Articles, Reviews, Mini-Reviews, based on but not limited to the following themes:

1) Identification and characterization of the bioactive polyphenols from novel resources.
2) Exploration of the structure-activity relationship of the polyphenols in different food storage and processing.
3) Absorption and metabolism of polyphenols using novel intestinal delivery techniques on metabolic syndrome-based models.
4) Bioactivities of polyphenols on metabolic syndrome and underlying molecular mechanisms.
5) Improvement of metabolic syndrome by polyphenol-contained diet from clinical trials.

Submit your idea

Impact

Frontiers in Nutrition

Participating Journals

Impact