The non-coding DNA have long been thought as junk DNA. However, it is becoming clear that at least some of the “junk DNAs” are integral to cell function, which are considered as regulatory DNA. Deep sequencing-based transcriptome profiling analysis showed that tumor-specific markers are not only involved in protein-coding genes but also in non-coding regulatory elements. The functional interpretation of regulatory non-coding regulatory regions is important but challenging. Cancer biology research faces many pressing challenges and uncertain results, which needs comprehensive resources and support.

Hence, this Research Topic mainly focuses on the latest developments in the regulatory mechanism of functional non-coding regulatory regions, including enhancers, super enhancers, silencers, and other non-coding regulatory regions, as well as related DNA and proteins involved in regulation (transcription factors, cofactors, chromatin regulators, methylation acetylation catalytic enzymes).

This Research Topic is interested in but not limited to the following sub-topics:
- Non-coding regulatory region-disease associations. For example, enhancer-disease associations, super-enhancer-disease associations, chromatin accessibility region-disease associations, and so on.
- Identification of non-coding regulatory region as therapeutic target, for example, mRNA, lncRNA, circRNA, and so on.
- The interaction between non-coding regulatory region and chromatin/transcript/protein.
- Technical updates of the current approaches used to identify functional non-coding regulatory region.
- Analysis and mining of upstream and downstream transcriptional regulatory networks related to non-coding regulatory regions.
- Defining landscape of non-coding regulatory regions in cancer by multi-omics profiling.
- The role of targeting complexes and targets related to non-coding regulatory regions in cancer.
- The role of non-coding regulatory regions-derived non-coding RNAs in cancer.

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.

Submit your idea

Impact

Frontiers in Oncology

Participating Journals

Impact