The final, formatted version of the article will be published soon.
REVIEW article
Front. Cell Dev. Biol.
Sec. Cell Death and Survival
Volume 13 - 2025 |
doi: 10.3389/fcell.2025.1522206
Dual Role of Pyroptosis in Liver Diseases: Mechanisms, Implications, and Therapeutic Perspectives
Provisionally accepted- Hunan Normal University, Changsha, China
Pyroptosis, a form of programmed cell death induced by inflammasome with a mechanism distinct from that of apoptosis, occurs via one of the three pathway types: classical, non-classical, and granzyme A/B-dependent pyroptosis pathways.Pyroptosis is implicated in various diseases, notably exhibiting a dual role in liver diseases. It facilitates the clearance of damaged hepatocytes, preventing secondary injury, and triggers immune responses to eliminate pathogens and damaged cells.Conversely, excessive pyroptosis intensifies inflammatory responses, exacerbates hepatocyte damage and promotes the activation and proliferation of hepatic stellate cells, accelerating liver fibrosis. Furthermore, by sustaining an inflammatory state, impacts the survival and proliferation of cancer cells. This review comprehensively summarizes the dual role of pyroptosis in liver diseases and its therapeutic strategies, offering new theoretical foundations and practical guidance for preventing and treating of liver diseases.
Keywords: pyroptosis, Liver disease, NLRP3, Inflammation, MAFLD
Received: 04 Nov 2024; Accepted: 10 Jan 2025.
Copyright: © 2025 Yang, Zou, Zhong, Peng, Zhou and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yunyi Zou, Hunan Normal University, Changsha, China
Chunhua Zhong, Hunan Normal University, Changsha, China
Xiyang Peng, Hunan Normal University, Changsha, China
Zuoqiong Zhou, Hunan Normal University, Changsha, China
Changfa Tang, Hunan Normal University, Changsha, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.