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REVIEW article

Front. Cell Dev. Biol.
Sec. Cellular Biochemistry
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1523958

Implication of protein post translational modifications in gastric cancer

Provisionally accepted
Mingze Zhang Mingze Zhang 1*Houji Song Houji Song 2Chengwang Guo Chengwang Guo 1*Xi Guo Xi Guo 1*Yuqi Ma Yuqi Ma 1*Yuntao Ma Yuntao Ma 3*
  • 1 The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
  • 2 Medical Research Institute, Southwest University, Chongqing, China
  • 3 Department of General Surgery, Gansu Provincial Hospital, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    Gastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, and its occurrence and development are regulated by multiple molecular mechanisms. Post-translational modifications (PTM) common forms include ubiquitylation, phosphorylation, acetylation and methylation. Emerging research has highlighted lactylation and glycosylation. The diverse realm of PTM and PTM crosstalk is linked to many critical signaling events involved in neoplastic transformation, carcinogenesis and metastasis. This review provides a comprehensive overview of the impact of PTM on the occurrence and progression of GC. Specifically, aberrant PTM have been shown to alter the proliferation, migration, and invasion capabilities of GC cells. Moreover, PTM are closely associated with resistance to chemotherapeutic agents in GC. Notably, this review also discusses the phenomenon of PTM crosstalk, highlighting the interactions among PTM and their roles in regulating signaling pathways and protein functions. Therefore, in-depth investigation into the mechanisms of PTM and the development of targeted therapeutic strategies hold promise for advancing early diagnosis, treatment, and prognostic evaluation of GC, offering novel insights and future research directions.

    Keywords: gastric cancer, Ubiquitination, Phosphorylation, Acetylation, Glycosylation, Methylation, lactylation, Sumoylation

    Received: 06 Nov 2024; Accepted: 10 Jan 2025.

    Copyright: © 2025 Zhang, Song, Guo, Guo, Ma and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Mingze Zhang, The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
    Chengwang Guo, The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
    Xi Guo, The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
    Yuqi Ma, The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, Gansu Province, China
    Yuntao Ma, Department of General Surgery, Gansu Provincial Hospital, Lanzhou, Gansu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.