About this Research Topic
As part of advancing this translational approach, increased investigation into the role of the immune system, as well as of inflammatory signalling cascades, in the pathogenesis and the progression of vasculitis is essential for improving our understanding and treatment of this group of diseases.
We welcome the submission of Original Research, Review, Mini-Review, Classification and Clinical Trial articles that discuss the following topics:
1. Improving the understanding of the immunological pathogenesis of vasculitis:
• Exploring the role of adaptive and innate immune cells in the development of vasculitis including T cells, B cells, neutrophils and ILCs.
• Improved measures for the classification of vasculitis diseases via the identification of shared immune signalling pathways that contribute to the pathogenesis of vasculitis.
• Identification of genetic determinants associated with the risk of developing vasculitis or particular subsets of disease.
• The role of the interplay between the microbiome and immune system in the pathogenesis of vasculitis as well as in influencing disease course.
2. Immune biomarkers in vasculitis
• Identification of factors associated with vasculitis outcome as well as response to therapy.
• Improvement of disease classification via the use of immune biomarkers.
• Biomarkers as tools to improve our understanding of the underlying immunopathology of this disease.
3. Identification of potential new therapeutic targets in the field of vasculitis
• Pilot therapeutic studies relying on surrogate translational outcomes of interest
• Associations of different targeted therapies and effects on immunological outcomes
• Immune biomarker guided disease sub-setting and treatment implications (for example, treatment approach in ANCA+ vs ANCA- ANCA associated vasculitis etc.)
Given the broad spectrum of organs involved in vasculitis, as well as the significant clinical heterogeneity, a wide range of specialists are involved in their management; we encourage experts with different backgrounds to contribute studies with a key immunological focus.
Keywords: vasculitis, biomarkers, ANCA
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.