About this Research Topic
Although ILCs are critical for tissue homeostasis and inflammatory processes, they are present only in very low numbers. Their scarcity belies their potency as ILCs are critical in regulating responses to pathogens, such as helminthic parasites, to maintain tissue integrity and promote immunological tolerance of T cells to commensal bacteria. Their dysregulation can lead to chronic inflammatory diseases including allergy and asthma and to autoimmune diseases such as colitis and Crohn’s disease. All ILC subsets have been shown to influence tumorigenesis, although their role to date appears highly ambiguous and are still requiring critical evaluation.
In this Research Topic, we aim to gather original cutting edge research covering aspects of the emerging field of ILCs in mucosal immunity and of the newly discovered role for ILCs in adipose tissue and metabolism. We welcome the submission of Original Research, Review and Perspective articles that address the following sub-topics:
1. ILC distribution and function at mucosal sites: gastrointestinal, respiratory and genitourinary.
2. ILCs and host:parasite interactions in gastrointestinal and respiratory sites.
3. ILCs and cancers at mucosal sites or in adipose tissue.
4. ILCs in human mucosal diseases.
5. ILCs in adipose tissue and metabolism.
6. ILCs and T cell crosstalk during mucosal immune responses.
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Keywords: Society affiliation RT
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