About this Research Topic
Although recent progress has been made with allogenic stem cell transplantation or IFN-/AZT treatment, current clinical treatments for ATL especially of its acute form are still woefully inadequate. In addition, treatment for other HTLV-1-related diseases are currently very disappointing.
Reviews in this issue will provide information of current status of our understanding of this unique retrovirus from the pathogenic point of view, covering the following topics of HTLV-1 research: mechanism of cell-to-cell transmission, adaptive and innate responses against the virus, signaling alteration caused by the different viral proteins, mechanisms of cell transformation, and molecular abnormalities in ATL cells. These articles will help to understand the unanswered questions in the field of HTLV-1 and related diseases, and provide future directions for HTLV-1 researchers.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.