Impact of Fruit and Flower Polyphenols on Lipid Metabolism and Cardiometabolic Health

Polyphenols are naturally occurring compounds found in a wide variety of fruits and flowers, recognized for their diverse health benefits, particularly in the prevention and management of lipid metabolism disorders. These compounds, which include flavonoids, phenolic acids, and tannins, possess potent antioxidant and anti-inflammatory properties that play a crucial role in protecting against oxidative stress and inflammation, both of which are key factors in the development of cardiometabolic diseases. Disruptions in lipid metabolism, such as elevated cholesterol and triglyceride levels, are major risk factors for conditions like hyperlipidemia, atherosclerosis, and metabolic syndrome, all of which contribute to cardiovascular disease. Increasing evidence suggests that polyphenols can modulate lipid profiles, enhance cholesterol efflux, inhibit lipid peroxidation, and improve endothelial function, thus offering promising therapeutic potential.

The rise in lipid metabolism disorders, such as hyperlipidemia and atherosclerosis, significantly contributes to the global burden of cardiometabolic diseases. While current treatments often rely on medications, these can have side effects and limited accessibility. Recent research has highlighted the potential of polyphenols from fruits and flowers as natural agents to regulate lipid metabolism, reduce inflammation, and lower cholesterol and triglyceride levels. To address this issue, the focus should be on exploring the molecular mechanisms of polyphenols, assessing their bioavailability, and testing their therapeutic potential through preclinical and clinical studies. This approach could lead to more effective, natural alternatives for preventing and managing lipid disorders and related complications.

This Research Topic aims to delve into the clinical and biochemical dynamics of fruit and flower polyphenols in the amelioration and prevention of lipid metabolism disorders, particularly how they impact cardiometabolic health. To further our understanding, the following themes are encouraged for submission:

• Investigating how polyphenols modulate lipid metabolism and improve cardiovascular health
• Exploring the role of polyphenols in reducing oxidative stress and inflammation.
• Examining the effects of polyphenols on cholesterol levels, triglycerides, and lipid profiles
• Assessing the absorption and efficacy of polyphenols in the human body
• Evaluating polyphenols as natural agents for treating and preventing lipid metabolism disorders
• Investigating the incorporation of polyphenols into dietary supplements and foods
• Identifying specific polyphenols in fruits and flowers and characterizing their health benefits

Keywords: Polyphenols, Edible fruits, edible flowers, lipid metabolism, metabolic syndrome, atherosclerosis, cardiovascular diseases

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