This Research Topic is the second volume of the Research Topic "Bone Aging and Osteoporosis: Recent Evidence Focusing on Plant-Based Natural Products" Please see the first volume (here)

Osteoporosis results from the body's imbalance between bone resorption and formation, a crucial aspect of bone metabolism altered adversely with age. This condition heightens fracture risks, especially in the elderly, and impacts a significant portion of the population, with one-third of women and one-fifth of men estimated to suffer from an osteoporotic fracture in their lifetime. The potential of plant-based natural products, or secondary metabolites like polyunsaturated fatty acids and flavonoids, is being recognized more in scientific circles for their roles in reducing risk factors and improving bone health, backed by traditional usage but requiring further clinical validation.

This Research Topic aims to deepen our understanding of the impact and mechanisms through which plant-based natural products contribute to the prevention and treatment of osteoporosis. We seek to provide comprehensive insights into their roles, backed by rigorous scientific investigation and verification of their effectiveness in both traditional and innovative applications.

Efforts will be concentrated on featuring studies that not only use animal models to investigate osteoporosis but also include extensive cellular level analysis involving osteoclasts, osteoblasts, and stem cells, among others. We invite researchers to contribute their findings through various scientific approaches including:

• Proteomics, metabolomics, and genomics
• Epigenetics and other omic technologies
• Clinical trials and case studies of plant-based products
• Comparative analyses of conventional and plant-based therapeutic practices

These studies will help in understanding the comprehensive role of natural products in osteoporosis and may bridge the gap from laboratory research to clinical use.

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Frontiers in Medicine

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