More than 12 % of the population have migraine, the second cause of disability in the world. It is noteworthy that episodic migraine is associated with different comorbidities, including psychiatric, sleep, and cardiovascular disease in and, even more in chronic migraine.

More recently, there is growing scientific research that amplifies experience of the patients with migraine, especially women who experience menstrual-related hormonal changes leading to a greater susceptibility to migraine attacks as well as pregnancy that can introduce set of challenges in treatment options and a higher frequency of pregnancy complications in women with migraine.

Similarly, although other well-known symptoms, such as neck pain, can be a complaint of patients with migraine, cervicogenic component and cervical spine conditions can be contributing factors to hard-to-treat headaches that deserve to be taken in appropriate consideration.

However, along with well-known frequent coexistent conditions and comorbidities, overlooked clinical pictures have been described as actually prevalent in patients with migraine and should be taking into the consideration when discussing the diagnosis and therapeutic management, such as – for the sake of example - the triade of postural orthostatic tachycardia syndrome (POTS), hypermobility spectrum disorders (HSD), and mast cell activation syndrome (MCAS).

The present Research Topic will highlight recent advancements in the pathophysiological understanding of the different conditions associated with migraine and explore innovative management of migraine in a clinical scenario of coexistences or comorbidities. Therefore, we will focus on all developments, including progress in diagnosis, therapy and future research that can move forward management of patients living with migraine.

We welcome all types of articles providing new insights from experimental models and clinical studies that can help in management of migraine in persons with comorbidities as well as migraine associated conditions.

Article types include, but are not limited to, original research, reviews, case series and literature reviews, and letters.

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Frontiers in Neurology

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