Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that affects metabolic and cardiovascular health, posing a significant risk for long-term cardiovascular complications. Women with PCOS often exhibit insulin resistance, dyslipidemia, and systemic inflammation, which contribute to mitochondrial dysfunction and metabolic inflexibility - key factors in the development of cardiovascular disease (CVD). These disturbances are associated with increased risks of hypertension, cardiac fibrosis, and endothelial dysfunction in PCOS patients.

This research topic focuses on the cardiovascular consequences of PCOS, specifically exploring the molecular mechanisms that drive cardiovascular dysfunction in this population. By investigating mitochondrial impairment, chronic inflammation, and metabolic dysregulation, the aim is to better understand the cardiovascular risks associated with PCOS and identify potential therapeutic strategies.

This research topic aims to foster a deeper understanding of the mechanisms driving cardiovascular dysfunction in PCOS, highlighting innovative strategies for prevention and treatment. By focusing on mitochondrial and inflammatory pathways, this topic will contribute to improving cardiovascular outcomes in women with PCOS.

In this Research Topic, we invite contributors to submit papers on the following topics, including but not limited to:

• Mitochondrial dysfunction as a driver of cardiovascular disease in PCOS.

• Chronic inflammation and its contribution to cardiac fibrosis and vascular dysfunction in PCOS.

• Metabolic dysregulation and its impact on cardiovascular outcomes in PCOS.

• Therapeutic potential of modulators such as short-chain fatty acids and HDAC inhibitors in mitigating cardiovascular risk in PCOS.

• Role of systemic insulin resistance and dyslipidemia in cardiovascular health in PCOS.

• Cross-talk between adipose tissue and the cardiovascular system in PCOS-related cardiometabolic dysfunction.

• Novel interventions targeting mitochondrial dysfunction and inflammation in cardiovascular disease associated with PCOS.

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Frontiers in Endocrinology

Submit your idea

Impact