Single Cell Technologies for the Interrogation of Immunological Disease Mechanisms: Volume 2

The skin is the human body's largest organ consisting of two layers: epidermis and dermis, and appendages: hair, and sweat glands. The skin not only wraps the body but also protects it from external stimuli and infection, perceives sensations such as pain and itch, and coordinates with various circulating immune cells for immune response/regulation. Recent studies have shown that inflammatory skin diseases, including psoriasis and atopic dermatitis, harbor systemic inflammation/immune abnormalities such as strong Th activation and expansion of specific immune cell subsets. Novel biologics and small molecule inhibitors targeting specific biomarkers and immune signals are much more effective and safer than conventional systemic therapies for these skin diseases.

This research topic focuses on the interaction between the skin and immune cells. The main goal of this research topic is to explore how skin cells and immune cells interact with each other and contribute to the pathogenesis of those skin diseases. In this research topic, we will reveal that skin and immune cells could "talk" in inflammatory skin diseases.

We welcome original research articles, review articles, meta-analyses, and clinical trials, which highlight the interaction of skin and immune cells from innovative research with new perspectives and/or challenges to overcome current problems. Current omics technology in dermatological research, based on genome, transcriptome, proteome, metabolome, interactome, and cellome, are very welcome in this research topic.

Keywords: Skin, Crosstalk, Omics technology

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.