About this Research Topic
Obesity affects approximately one-third of adults in modern society and is a significant risk factor for diabetes, a threatening metabolic disease. It is also closely associated with several ectopic disorders, including fatty liver, atherosclerosis, and cardiovascular diseases. Classic brown fat and newly identified beige fat within white fat can activate thermogenesis in response to cold stimulation, catecholamines, and agonists. Activating brown and beige fat in adults to burn excess fatty acids and glucose has been shown in animal models to ameliorate obesity-induced diabetes and fatty liver.
This Research Topic aims to comprehensively include studies and reviews that provide new insights into the molecular mechanisms and therapeutic applications of activating brown and beige fats to target obesity, diabetes, and fatty liver.
Potential sub-topics can include the following but are not limited to:
● Molecular mechanisms of brown and beige adipose tissue development
● Translational potential of brown and beige adipose tissue on targeting human metabolic diseases, such as obesity and diabetes
● Organ tissue interaction between brown/beige fat and other organs, such as liver, brain and muscle, and islets
● Involvement of tissue immune cells on brown and beige fat activation
● Sympathetic innervation and brain-fat communications on activation of brown and beige fat.
This Research Topic aims to comprehensively include studies and reviews that provide new insights into the molecular mechanisms and therapeutic applications of activating brown and beige fats to target obesity, diabetes, and fatty liver.
Potential sub-topics can include the following but are not limited to:
● Molecular mechanisms of brown and beige adipose tissue development
● Translational potential of brown and beige adipose tissue on targeting human metabolic diseases, such as obesity and diabetes
● Organ tissue interaction between brown/beige fat and other organs, such as liver, brain and muscle, and islets
● Involvement of tissue immune cells on brown and beige fat activation
● Sympathetic innervation and brain-fat communications on activation of brown and beige fat.
Keywords: Obesity, Thermogenesis, Brown adipocyte, Beige adipocyte, UCP1
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