Central Metabolic Dysregulation profoundly influences the health and well-being of animals, including humans, affecting global physiological functions across numerous systems. Although a diverse body of research has shed light on various aspects of metabolic dysfunction, significant gaps remain in our understanding of the neuroendocrine interactions and metabolic processes integral to these conditions. Current interventions are insufficient due to these incomplete insights, thus necessitating a deeper exploration into existing mechanisms and potential new interventions.

This Research Topic aims to consolidate the latest advances in the study of metabolic dysregulation, emphasizing the intricate play between neuroendocrine factors and metabolic responses. It seeks to outline the current landscape and pinpoint future research directions that could lead to effective treatment modalities. Ultimately, the goal is to broaden the understanding that connects molecular findings to clinical applications, fostering a translational approach to tackling metabolic disorders.

In the present Research Topic, we welcome the submission of original research, reviews, perspectives, general commentaries, and opinion article types that explore a broad array of themes related to this research area.

We welcome articles addressing, but not limited to, the following themes:

• Effects of metabolites and hormones on hypothalamic control of energy balance.
• The role of metabolites as modulators of mitochondrial function.
• Interdisciplinary, translational, and clinical research regarding the physiology of metabolism.
• Understanding the interaction between peripheral, metabolic, and neuronal function and its contribution to metabolic disorders.
• Advances in imaging technology for visualization of central vasculature.
• Mapping pathways related to malnutritional exposure.
• Determination of metabolic biomarkers that predict central and peripheral dysfunction.
• Role of GPCRs in regulating neurotransmitter effects on secretory processes.
• Mechanisms regulating vesicle exocytosis across various cell types.
• G protein interactions with cellular machinery in metabolic regulation.
• Discussion of future research directions that require further investigation.

Contributions should focus on all levels of investigation, from molecular to organism level. Clinical research studies will only be considered if they directly relate to metabolic physiology.

Topic Editors Dr. Jennifer F. Thorson and Dr. Ligia D. Prezotto declare for transparency that they are in a familial relationship.

Submit your idea

Impact

Frontiers in Physiology

Submit your idea

Impact