Multiple Sclerosis (MS) is a chronic, often disabling disease of the central nervous system that disrupts the flow of information within the brain and between the brain and body. One of the common and debilitating complications associated with MS is Lower Urinary Tract Dysfunction (LUTD). LUTD in MS patients can manifest as a range of symptoms, from urinary urgency and frequency to urinary retention and incontinence, significantly impacting quality of life. This research topic aims to gather cutting-edge research on the pathophysiology, diagnosis, and management of LUTD in MS patients to improve patient outcomes.

The management of LUTD in MS is complex due to the variable nature of the disease and the multifaceted impact on the urinary system. While there have been strides in understanding the neurological underpinnings of LUTD in MS, there is a pressing need for comprehensive strategies that integrate novel diagnostic tools, therapeutic interventions, and patient-centered care models. This collection will provide a platform for clinicians, researchers, and other healthcare professionals to share insights, innovations, and best practices in managing MS-related LUTD.

The aim of this Research Topic is to explore the pathophysiological mechanisms underlying LUTD in MS patients, to evaluate the diagnostic methodologies, assess therapeutic interventions and patient care and highlight emerging research. We welcome original research and review articles that include, but are not limited to, the following topics:

1. Neurophysiology of MS-related LUTD- Current understanding and future directions in neurogenic mechanisms.

2. Advances in diagnostic tools- Urodynamic studies and biomarkers in MS.

3. Pharmacological treatments- Efficacy and safety profiles of novel drug therapies.

4. Non-pharmacological interventions- Role of neuromodulation and behavioural therapies.

5. Patient-reported outcomes and quality of life assessments- Impact of LUTD on daily living and long-term health outcomes.

6. Interdisciplinary management approaches- Integrating neurology, urology, physiotherapy, and nursing care.

This collection will serve as a comprehensive resource for understanding and managing MS-related LUTD. By compiling the latest research and facilitating the exchange of knowledge among experts, this initiative aims to drive forward improvements in clinical practice and patient care.

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Frontiers in Urology

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