About this Research Topic

Background

Nonallergic Rhinitis (NAR) represents a complex group of conditions that, while mimicking the symptoms of Allergic Rhinitis (AR), such as nasal congestion, runny nose, and sneezing, do not involve an allergic immune response. The management of NAR is particularly challenging due to the diversity of its underlying mechanisms across different subtypes.

At the forefront of NAR treatments are Intranasal Corticosteroids, recognized for their efficacy in reducing inflammation, swelling, and mucus production within the nasal passages. These are widely accessible in both prescription and over-the-counter formulations. Similarly, Intranasal Antihistamines, though not targeting allergic reactions per se, are beneficial for alleviating symptoms like postnasal drip and sneezing.

Further along the treatment spectrum are Intranasal Anticholinergics such as ipratropium bromide, which effectively curtails excessive nasal mucus secretion and are particularly useful for persistent runny noses. Complementary to these pharmacological agents is Saline Irrigation, which aids in clearing nasal passages of irritants and mucus, thus mitigating nasal congestion.

An adjunctive treatment option, Decongestants, offers immediate relief from nasal stuffiness, though they must be used judiciously to avoid the risk of rebound congestion. Capsaicin Sprays, though unconventional, have demonstrated their worth by desensitizing nasal nerves and decreasing congestion and runny nose symptoms with regular use.

Further from the mainstream, Oral Leukotriene Antagonists like montelukast have shown promise, particularly for those NAR patients who also suffer from asthma, hinting at overlapping therapeutic pathways that could benefit multiple conditions.

Emerging alternative therapies such as acupuncture and homeopathy are under investigation with initial studies pushing for more rigorous research to validate their effectiveness fully.

Understanding that NAR often co-exists with other conditions like respiratory infections or hormonal imbalances, it becomes essential to adopt a holistic approach in its management. This involves recognizing and addressing potential exacerbating factors such as environmental irritants or lifestyle choices.

Our call is for research that dives deeper into:
• Comparative studies on the efficacy of existing and novel treatments.
• Longitudinal analyses assessing the long-term outcomes of therapeutic interventions.
• Innovative medical strategies that integrate pharmacologic treatments with lifestyle and environmental modifications.

Given the heterogeneity of Nonallergic Rhinitis and its impact on quality of life, there is a continuous need for tailored, multi-modal treatment strategies that cater not only to symptom relief but also to the nuanced needs of individual patients. This research topic seeks contributions that will shed new light on these diverse therapies, enhancing our understanding and management of NAR.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Community Case Study
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

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Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Community Case Study
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review

Keywords: Nonallergic rhinitis (NAR), Intranasal corticosteroids, Anticholinergic therapy, Montelukast, Complementary therapies, Lifestyle modifications in NAR, Environmental irritants and NAR, Long-term outcomes of NAR treatments, Comparative efficacy studies

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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