About this Research Topic
Delving into the complex network of host-pathogen interactions in tuberculosis, this topic unveils the crucial role of proteins in shaping the pathophysiology of the disease. Understanding these interactions equips researchers and clinicians with a profound understanding of tuberculosis dynamics and highlights potential targets for intervention. The intricate interplay between host and pathogen proteins significantly influences virulence and pathogenesis, offering insights into the mechanisms underlying TB infection. By exploring these protein interactions, the topic aims to advance knowledge and develop innovative strategies to combat tuberculosis. This research is pivotal in achieving the World Health Organization's goal of eradicating TB by 2035, providing a comprehensive view of the molecular and cellular interactions critical to TB pathogenesis and highlighting new avenues for therapeutic intervention.
This topic aims to thoroughly investigate the mechanistic roles of host and TB pathogen proteins in shaping the outcomes of Mycobacterium tuberculosis infections, with a particular focus on their influence on innate and adaptive immunity. By elucidating these roles, our goal is to significantly enhance the understanding of TB pathomechanisms, shedding light on the complex interplay between host defenses and M. tb infection. This exploration will establish a robust foundation for the development of precise strategies aimed at mitigating tuberculosis. Furthermore, we seek to explore key regulatory pathways and protein factors governing host-pathogen interactions to harness this knowledge for the design and implementation of innovative approaches that effectively combat TB. Through this integrative approach, we anticipate not only uncovering the intricate mechanisms driving TB infection but also identifying new therapeutic targets and preventive measures crucial for addressing this pressing global health challenge.
We invite authors to contribute to a comprehensive synthesis of recent advancements in tuberculosis research. Significant progress has enriched our understanding of host-pathogen interactions, presenting an opportunity for a new publication to incorporate these latest findings and offer updated insights into TB virulence strategies and pathomechanisms. Authors are encouraged to spotlight emerging therapeutic targets among host and TB pathogen proteins, exploring their potential in innovative TB mitigation strategies, including host-directed and pathogen-host interface-based therapeutics. Additionally, the publication seeks to integrate multidisciplinary approaches, drawing from microbiology, immunology, molecular biology, and cell biology to provide a holistic perspective on TB pathophysiology and host-pathogen interactions. By synthesizing current knowledge and proposing practical strategies, this publication aims to advance efforts in combating TB and improving global health outcomes.
The topic editors declare that they have no conflicts of interest in relation to the editorship of this collection.
This topic aims to thoroughly investigate the mechanistic roles of host and TB pathogen proteins in shaping the outcomes of Mycobacterium tuberculosis infections, with a particular focus on their influence on innate and adaptive immunity. By elucidating these roles, our goal is to significantly enhance the understanding of TB pathomechanisms, shedding light on the complex interplay between host defenses and M. tb infection. This exploration will establish a robust foundation for the development of precise strategies aimed at mitigating tuberculosis. Furthermore, we seek to explore key regulatory pathways and protein factors governing host-pathogen interactions to harness this knowledge for the design and implementation of innovative approaches that effectively combat TB. Through this integrative approach, we anticipate not only uncovering the intricate mechanisms driving TB infection but also identifying new therapeutic targets and preventive measures crucial for addressing this pressing global health challenge.
We invite authors to contribute to a comprehensive synthesis of recent advancements in tuberculosis research. Significant progress has enriched our understanding of host-pathogen interactions, presenting an opportunity for a new publication to incorporate these latest findings and offer updated insights into TB virulence strategies and pathomechanisms. Authors are encouraged to spotlight emerging therapeutic targets among host and TB pathogen proteins, exploring their potential in innovative TB mitigation strategies, including host-directed and pathogen-host interface-based therapeutics. Additionally, the publication seeks to integrate multidisciplinary approaches, drawing from microbiology, immunology, molecular biology, and cell biology to provide a holistic perspective on TB pathophysiology and host-pathogen interactions. By synthesizing current knowledge and proposing practical strategies, this publication aims to advance efforts in combating TB and improving global health outcomes.
The topic editors declare that they have no conflicts of interest in relation to the editorship of this collection.
Keywords: Host-pathogen, interactions, tuberculosis, proteins, pathophysiology, virulence, pathogenesis, Mycobacterium, immunity, regulatory, pathways, infection, mechanisms, therapeutic targets.
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