This Research Topic is Volume III of a series. The previous volume, which has attracted over 52,000 views can be found here: Bioengineering and Biotechnology Approaches in Cardiovascular Regenerative Medicine, Volume II.

The heart is one of the most complex and hardworking organs of the human body, wondrously choreographed to contract, conduct, and pump the blood through the vascular system, to provide fuel for all the vital functions. Salvage and repair of the human heart has been a long-sought goal and ambition of many researchers, given its notorious incapacity to regenerate following injury or disease. Cardiovascular regenerative medicine, characterized by a unique integration of biology, physical sciences, and bioengineering principles, has emerged as one of the most promising fields of translational research to regenerate the adult human heart. The proper incorporation and integration of diverse bioengineering-biotech tools into such tissue regenerative endeavors could lead to off-the-shelf bioartificial organs that are suitable for transplantation or other clinical therapies.

Therefore, ever-growing attention has been given to the advancement of various bioengineering-biotech principles and their implementation in cardiac regenerative medicine. The previous volumes consisted of 30 articles and covered emerging topics in Cardiovascular Science, including engineered tissue transplantation, cardiac cell reprogramming, nanoparticles, human-induced pluripotent stem cell-derived cardiomyocyte, cardiac regeneration, and machine learning & bioinformatics applications.

This Research Topic aims to focus on the most recent advancements in the development of advanced bioengineering and biotechnological tools and their use in cardiovascular regenerative medicine, both as biomimetic platforms for in vitro disease modeling or drug screening, and for therapeutic applications in vivo. In this third volume, our goal is to continue the success of previous topic volumes and promote the utilization of artificial intelligence – big data techniques in discovering new approaches to treating cardiovascular diseases.

This article collection will cover a wide spectrum of research subjects including (but not limited to):

 Advanced bio-manufacturing methodologies to create functional cardiovascular tissues;
 Engineered cellular and molecular systems to regenerate heart tissue;
 Biomaterial systems for in vitro or in vivo regenerative therapies;
 Bioengineered culture systems for cardiovascular disease modeling
 Advanced technologies to evaluate engineered tissues
 Tissue-engineered scaffolds for controlled drug delivery and release; and
 Cardiac cell-ECM interactions.

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