The S-CoV-2 pandemic has been a complex epidemiological phenomenon. The increase in virus variants has made it more challenging to control virus outbreaks. Although the incidence of other respiratory viral diseases decreased during the pandemic, the incidence of other viral infections, such as dengue infection, increased. The involvement of immune response is crucial to understand the phenomenon. The present proposal aims to revise the topic of viral infection, replication, coinfection, and escape along the importance of immune response in these events.

The aim of the project is to analyze the complex phenomenon of SARS-CoV-2 infection, reinfection and chronicity along other viral infections. We welcome the submission of Original Research, Review, and Mini-review articles focusing on, but not limited to, the following questions:

1. Is SARS-CoV-2 generating enhancing the frequency of infection by hampering proper antiviral responses?

2. Is the host lack of proper viral responses the reason of co infection and viral chronicity?

3. How can the process of infection can be modulated by vaccination or antiviral therapy?

4. In addition, what other new elements shall be taken into account for new pathogens? Are we prepared?

There have been several reports of the increase incidence of infections in patients during SARS-CoV-2 infection and after SARS-CoV-2 infection and little is known about the mechanism. In addition, long-COVID cases have increased suggesting an impaired immune response in which autoimmunity and secondary immune deficiency have been proposed as critical in the management of pathogen co infection. Age has been considered a risk factor as well as several comorbidities; however, there are still important points to analyze in viral infection and immune response.

The topic editors declare no conflicts of interest in relation to the management and editorship of this collection.

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Frontiers in Immunology

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