Gastrointestinal (GI) cancer encompasses a group of malignancies affecting the digestive tract and related organs, including cancers of the colon, pancreas, stomach, liver, and esophagus. These cancers are characterized by high morbidity and mortality rates globally, signaling a pressing need for intensified research and innovative treatment strategies. Epigenetics plays a pivotal role in the pathogenesis of cancers by controlling gene function and expression through mechanisms such as DNA methylation, histone modification, non-coding RNA regulation, and chromatin remodeling. Despite significant progress in utilizing epigenetic abnormalities for tumor marker identification and epigenetic drug development, the specific epigenetic mechanisms underlying GI cancers remain poorly understood.

This Research Topic aims to delve into the recent advancements in understanding and manipulating the epigenetic landscape in gastrointestinal cancer. It seeks to provide a comprehensive platform for disseminating research on the mechanistic insights, potential biomarkers, and innovative therapeutic targets offered by epigenetic studies. By focusing on these areas, the research intends to highlight emerging therapeutic strategies and enhance the clinical management of GI cancers.

This topic is scoped to explore the frontiers of epigenetic research within gastrointestinal cancer realms. In order to refine the research boundaries and provide focused insights, our initiative strictly centers on:
Epigenetic mechanisms specific to gastrointestinal cancer progression.
Innovative therapeutic approaches leveraging epigenetic targets in GI cancer treatment.
To gather further insights, we welcome articles addressing, but not limited to, the following themes:
Epigenetic regulation during gastrointestinal cancer development.
Comprehensive reviews of recent epigenetic advances in gastrointestinal tumors.
Research on interventions or new drugs targeting key epigenetic enzymes and targets in gastrointestinal cancer.
Studies identifying new pathways through which epigenetic modifications alter gastrointestinal cancer risks.

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Frontiers in Cell and Developmental Biology

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