Septic arthritis (SA) is a complex clinical condition associated with significant morbidity and mortality. Despite its rarity, it poses a significant challenge in the field of orthopedics due to its potential to severely impact patients' quality of life. The condition is often diagnosed through a combination of clinical symptoms, laboratory work, and imaging techniques. However, the current state of knowledge reveals gaps in understanding the risk factors, optimal treatment strategies, and long-term outcomes of patients with SA. Recent studies have highlighted the role of various factors such as age, comorbidities, and specific pathogens in influencing mortality rates among SA patients. However, there is a need for a better investigation into the intricate interplay of these factors and their role in the prognosis of SA.

The primary aim of this research topic is to delve deeper into the clinical outcomes of patients with septic arthritis and identify potential predictors of treatment failure. The research will also aim to explore the overall mortality rates among SA patients and analyze factors that might contribute to the risk of death. Furthermore, the research will seek to test the hypothesis that the absence of a joint effusion on pre-procedure advanced imaging could reliably predict a dry tap and exclude septic arthritis. The research will also aim to investigate if arthroscopic washout for native knee septic arthritis confers a lower risk of repeat procedure than arthrotomy.

To gather further insights into the clinical outcomes, risk factors, and treatment strategies for septic arthritis, we welcome all article types addressing, but not limited to, the following themes:

• The role of specific pathogens in the development and progression of septic arthritis.

• The impact of comorbidities on the prognosis of patients with septic arthritis.

• The efficacy of various treatment strategies, including arthroscopic washout and arthrotomy, in managing septic arthritis.

• The potential predictors of treatment failure in patients undergoing two-stage total joint replacement for hip and knee septic arthritis.

• The long-term outcomes of patients with septic arthritis, including the risk of developing postinfectious osteoarthritis.

• Microbiological profiles and their influence on treatment response.

• The role of imaging in the diagnosis and management of septic arthritis.

• Antibiotic resistance patterns in septic arthritis.

• The role of emerging therapies, including biological agents.

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Frontiers in Medicine

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