About this Research Topic
This Frontiers Research Topic is interested in better understanding the underlying effects of chronic hyperglycemia on cellular health, specifically its role in inducing oxidative stress and inflammation. This phenomenon affects the susceptibility of key organelles—particularly the mitochondria (the cell's energy powerhouses), the endoplasmic reticulum (ER, involved in protein folding and secretion), and lysosomes (responsible for waste breakdown and recycling)—which play critical roles in the development of metabolic changes across various organs in the body.
Studies exploring how chronic metabolic stress leads to organelle burnout are also of great interest to this collection. We particularly encourage investigations into the signalling pathways regulating unfolded protein response (UPR, a cellular stress response related to the ER) and mitochondrial dysfunction, which drive inflammation and cell death, contributing to tissue damage in metabolic diseases.
With dietary changes and environmental factors playing an increasing role in health outcomes, we welcome contributions that examine the complex interplay between hyperglycemia, organelle dysfunction, and the gut microbiome. The imbalance in the microbiome (dysbiosis) and its contribution to systemic inflammation and organelle dysfunction could be key areas of focus.
Submissions are encouraged to explore innovative therapeutic strategies designed to enhance cellular resilience and preserve organelle function. These strategies may include, but are not limited to antioxidants (molecules that neutralize free radicals), mitochondrial enhancers, ER stress inhibitors, and gut microbiome-targeted interventions for mitigating the progression of diabetes-related complications by improving the health and function of these organelles.
Studies should provide comprehensive data, robust analysis, and clear implications for future research and clinical applications. We aim to foster interdisciplinary dialogue and innovation in diagnostics and therapeutic strategies.
Suggested topics for submission:
• Chronic hyperglycemia and its impact on organelle function
• The role of the unfolded protein response (UPR) in diabetes-related inflammation
• Mitochondrial dysfunction and oxidative stress in metabolic diseases
• Dysbiosis and the gut microbiome’s influence on metabolic flexibility in metabolic diseases
• Therapeutic approaches to preserve organelle health in the context of metabolic diseases
• Novel diagnostics for early detection of organelle burnout in hyperglycemia
We look forward to receiving your groundbreaking contributions that will deepen our understanding of the interactions among hyperglycemia, organelle health, and the gut microbiome in metabolic diseases. Manuscripts may include experimental research, lab protocols, technical reports, clinical studies, and molecular epidemiology studies.
Studies exploring how chronic metabolic stress leads to organelle burnout are also of great interest to this collection. We particularly encourage investigations into the signalling pathways regulating unfolded protein response (UPR, a cellular stress response related to the ER) and mitochondrial dysfunction, which drive inflammation and cell death, contributing to tissue damage in metabolic diseases.
With dietary changes and environmental factors playing an increasing role in health outcomes, we welcome contributions that examine the complex interplay between hyperglycemia, organelle dysfunction, and the gut microbiome. The imbalance in the microbiome (dysbiosis) and its contribution to systemic inflammation and organelle dysfunction could be key areas of focus.
Submissions are encouraged to explore innovative therapeutic strategies designed to enhance cellular resilience and preserve organelle function. These strategies may include, but are not limited to antioxidants (molecules that neutralize free radicals), mitochondrial enhancers, ER stress inhibitors, and gut microbiome-targeted interventions for mitigating the progression of diabetes-related complications by improving the health and function of these organelles.
Studies should provide comprehensive data, robust analysis, and clear implications for future research and clinical applications. We aim to foster interdisciplinary dialogue and innovation in diagnostics and therapeutic strategies.
Suggested topics for submission:
• Chronic hyperglycemia and its impact on organelle function
• The role of the unfolded protein response (UPR) in diabetes-related inflammation
• Mitochondrial dysfunction and oxidative stress in metabolic diseases
• Dysbiosis and the gut microbiome’s influence on metabolic flexibility in metabolic diseases
• Therapeutic approaches to preserve organelle health in the context of metabolic diseases
• Novel diagnostics for early detection of organelle burnout in hyperglycemia
We look forward to receiving your groundbreaking contributions that will deepen our understanding of the interactions among hyperglycemia, organelle health, and the gut microbiome in metabolic diseases. Manuscripts may include experimental research, lab protocols, technical reports, clinical studies, and molecular epidemiology studies.
Keywords: metabolic physiology, microbiome, hyperglycemia, inflammation, diabetes
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
