Basic Research and Clinical Application of Stem Cells in Endometrial Injury Repair and Endometriosis Treatment

Endometrial injury, caused most by artificial abortion and repeated intrauterine operation, is a common pathological process in the development of obstetric and gynecological diseases. Accompanied by the change in uterine environment, female hormone secretion and endometrial tolerance, it damages female fertility greatly. Endometriosis is a chronic inflammatory disease associated with endometrial injury, which affects approximately 10% of reproductive-age women and girls in the globe. However, conventional therapy in clinical practice cannot solve the problem of endometrial repair in severe patients. In recent years, stem cells have become a hot topic under research due to their high self-renewal ability and multi-directional differentiation potential. With the development of stem-cell biotechnology, stem-cell transplantation has become an effective intervention for many diseases. Stem cells can differentiate into endometrial, vascular smooth muscle, and endothelial cells, thus promoting endometrial regeneration and angiogenesis. Moreover, stem cells are characterized by the ability to secrete a variety of biologically active molecules, low-immunogenicity, and immunomodulatory properties. Generally, stem cell therapy exhibits broad clinical application prospects in endometrial injury repair and endometriosis treatment.

This research topic is aimed at bringing together basic research and clinical trials to comprehensively evaluate the safety of stem cells and delve into more characteristics of various emerging stem cells along with their specific molecular mechanisms and biological functions. It can also help understand the pathophysiology of endometriosis and finally explore new treatments, even prevention measures, for endometriosis. Combining stem cells and tissue engineering, we hope stem cell therapy can be further taken from bench to bedside, at the end achieving the goal of improving the quality of life for patients with endometriosis and better treating infertile women due to endometrial injury.
We welcome submissions on the following topics, but are not limited to:
● Characteristics and biological functions of more emerging stem cells
●Specific molecular mechanisms of stem cells in endometrial injury repair
● New technologies for stem cell transplantation in clinical practice
●Discussion on the safety and ethical issues of stem cell-based therapy for human diseases
●The role of stem cells in the pathophysiology of endometriosis and treatment for endometriosis
●Research on biological characteristics of stem cells in the microenvironment after transplantation

Keywords: stem cells; endometrium; endometrial injury repair; endometriosis; treatment

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