Osteocytes, the most abundant cells in bone tissue, have long been underestimated in their functional capacity. Traditionally viewed as passive entities, recent research has illuminated their pivotal roles in maintaining bone health and systemic physiological balance. These cells, which originate from osteoblasts and are embedded within the bone matrix, are now recognized as key regulators of bone mass and density. They achieve this by orchestrating the activities of osteoblasts and osteoclasts, the cells responsible for bone formation and resorption, respectively. Furthermore, osteocytes are integral to the remodeling of the extracellular matrix, ensuring the homeostasis of essential minerals like calcium and phosphate. Their mechano-sensitivity allows them to respond to physical stimuli, adapting bone structure accordingly. Beyond their skeletal functions, osteocytes have emerged as endocrine cells, influencing various organ systems such as the brain, liver, and immune system, thereby contributing to whole-body homeostasis. Despite these advances, the precise mechanisms of osteocyte-mediated intercellular communication and their roles in pathological conditions remain inadequately explored, necessitating further investigation.

This research topic aims to delve into the multifaceted roles of osteocytes, addressing their biological functions and interactions within and beyond the skeletal system. The primary objectives include elucidating the mechanisms of osteocyte communication with other cell types, understanding their interactions with the extracellular matrix, and exploring their endocrine functions. Additionally, the research seeks to investigate the impact of osteocytes on bone-related diseases and their systemic effects on other organs. By addressing these questions, the research aims to enhance our understanding of osteocyte biology and its implications for bone health and systemic diseases.

To gather further insights into the complex roles of osteocytes, we welcome articles addressing, but not limited to, the following themes:
- Osteocyte biology and function.
- Mechanobiology of osteocytes.
- Interactions between osteocytes and the extracellular matrix.
- Cellular communication between osteocytes and other cell types.
- The role of osteocytes in aging, osteoporosis, bone tumors, and other bone-related diseases.
- Inter-organ communication involving osteocytes and their systemic effects.

Submit your idea

Impact

Frontiers in Cell and Developmental Biology

Submit your idea

Impact