About this Research Topic
Gastric cancer is one of the leading global causes of cancer-related deaths and it remains one of the most challenging malignancies to deal with or treat. Emerging evidence suggests that the human gut microbiome and microbial dysbiosis, particularly involving Helicobacter pylori, play crucial and pivotal roles in its etiology, progression and treatment. Thus, a clear understanding of the interactions between gut microbiota and gastric cancer has the potential to lead to novel preventive and therapeutic strategies against this malignancy.
The primary goal of this research topic is to elucidate the interactions between the gut microbiome and gastric cancer. This includes identifying specific microbial profiles associated with cancer risk, understanding the mechanisms through which microbiota influence cancer progression and treatment, and evaluating the potential of leveraging these microbial interactions through the use live biotherapeutic products (LBPs), probiotics, and microbial & nutritional bioactive substances or metabolites to innovate preventive strategies and therapeutic interventions for gastric cancer, to mitigate cancer risk or support recovery post-treatment. By unravelling the complex interplay between the gut microbiome and this devastating disease, there is great potential to identify and develop novel and effective microbiome-based approaches to reduce cancer risk and improve patient outcomes.
We invite researchers to submit original research articles, reviews and mini-reviews that contribute to a deeper understanding of the gut microbiome’s role in gastric cancer and its potential as a target for innovative prevention and treatment strategies. By fostering interdisciplinary collaboration, this Research Topic seeks to advance the field of microbiome oncology and improve clinical outcomes for gastric cancer patients. The findings from this research could lead to breakthroughs in preventive strategies and therapeutic options for gastric cancer, potentially reducing its incidence and improving survival rates.
Key themes of interest may include but not limited to:
• An understanding of the specific changes in the gut microbiota associated with gastric cancer development and mechanistic insights into how specific microbial taxa and communities contribute to risk and severity of gastric carcinogenesis.
• Evaluation of the roles of Helicobacter pylori and other microorganisms, alone or in combination, in the development and progression of gastric cancer.
• Decoding the molecular and cellular mechanisms by which gut microbiota influences gastric carcinogenesis, including chronic inflammation, immune response modulation, and alteration of the gastric mucosal cells.
• Exploring the development and efficacy of specific strains of probiotics and LBPs to mitigate the risk or progression of gastric cancer, or aid in recovery post-treatment.
• Identify specific nutritional and bioactive compounds & metabolites produced by gut microbiota that may have anti-cancer properties and therapeutic potentials.
• Investigate the potential of combining conventional treatments with microbiome-modulating therapies for improved disease outcomes. Assessment of dietary and lifestyle factors influencing the gut microbiome and their implications for gastric cancer prevention.
The primary goal of this research topic is to elucidate the interactions between the gut microbiome and gastric cancer. This includes identifying specific microbial profiles associated with cancer risk, understanding the mechanisms through which microbiota influence cancer progression and treatment, and evaluating the potential of leveraging these microbial interactions through the use live biotherapeutic products (LBPs), probiotics, and microbial & nutritional bioactive substances or metabolites to innovate preventive strategies and therapeutic interventions for gastric cancer, to mitigate cancer risk or support recovery post-treatment. By unravelling the complex interplay between the gut microbiome and this devastating disease, there is great potential to identify and develop novel and effective microbiome-based approaches to reduce cancer risk and improve patient outcomes.
We invite researchers to submit original research articles, reviews and mini-reviews that contribute to a deeper understanding of the gut microbiome’s role in gastric cancer and its potential as a target for innovative prevention and treatment strategies. By fostering interdisciplinary collaboration, this Research Topic seeks to advance the field of microbiome oncology and improve clinical outcomes for gastric cancer patients. The findings from this research could lead to breakthroughs in preventive strategies and therapeutic options for gastric cancer, potentially reducing its incidence and improving survival rates.
Key themes of interest may include but not limited to:
• An understanding of the specific changes in the gut microbiota associated with gastric cancer development and mechanistic insights into how specific microbial taxa and communities contribute to risk and severity of gastric carcinogenesis.
• Evaluation of the roles of Helicobacter pylori and other microorganisms, alone or in combination, in the development and progression of gastric cancer.
• Decoding the molecular and cellular mechanisms by which gut microbiota influences gastric carcinogenesis, including chronic inflammation, immune response modulation, and alteration of the gastric mucosal cells.
• Exploring the development and efficacy of specific strains of probiotics and LBPs to mitigate the risk or progression of gastric cancer, or aid in recovery post-treatment.
• Identify specific nutritional and bioactive compounds & metabolites produced by gut microbiota that may have anti-cancer properties and therapeutic potentials.
• Investigate the potential of combining conventional treatments with microbiome-modulating therapies for improved disease outcomes. Assessment of dietary and lifestyle factors influencing the gut microbiome and their implications for gastric cancer prevention.
Keywords: Gastric cancers, gut microbiome, Helicobacter pylori, dysbiosis, risk associations, disease modulation, live biotherapeutic products, probiotics, microbial bioactive factors, dietary modulation of biotics, postbiotics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
