This collection is a continuation of Graft Preservation.

Recent advances in graft preservation have marked a significant improvement in transplant outcomes in solid organ transplants. The integration of ex vivo machine perfusion techniques has revolutionized the process by enlarging the donor organ pool and allowing the use of organs that previously might not have been considered due to their marginal status. This technology offers protection against the damages that arise from static cold storage, thereby reducing rates of primary graft dysfunction and reviving the functionality of previously marginal organs. Moreover, machine perfusion has successfully extended the viability of organs such as kidneys, livers, lungs, and hearts beyond traditional preservation times. This extension has opened new avenues for administering therapeutic agents during the preservation period to enhance organ quality and minimize post-transplant complications. These therapies range from conventional drugs to cutting-edge gene and cell therapies, illustrating a leap toward more dynamic and beneficial preservation strategies.

This Research Topic aims to harness and synthesize the latest advances in graft preservation to form a comprehensive body of knowledge that addresses the current shortcomings and explores future possibilities. The primary goal is to curate a collection of diverse contributions, including opinions, original research across clinical, translational, and basic studies, innovative approaches, detailed case reports, and in-depth reviews. These works should expand our understanding of ex vivo perfusion applications, challenge existing paradigms, and showcase novel avenues for further scientific exploration and clinical application.

To gather further insights in the evolving practice of graft preservation, we welcome articles addressing, but not limited to, the following themes:
- Regional practices using ex vivo perfusion and/or in situ perfusion techniques.
- The interplay of ex vivo perfusion with regenerative medicine.
- Innovations in perfusion devices, protocols, and preservation solutions.
- New tools for the assessment of the quality of the organ with focus on biomarkers.
- Strategies to expand the donor pool by employing marginal donors.
- Reimbursement strategies for the clinical use of modern preservation technologies.
- Exploring the role of ex vivo perfusion in xenotransplantation.

By integrating these facets with emerging technologies and fostering new collaborations, this second volume aims to accelerate the scientific advancement of graft preservation strategies, setting the stage for the next frontier in organ transplantation.

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Frontiers in Cardiovascular Medicine

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