About this Research Topic
Ischemic heart disease (IHD) is the leading cause of death worldwide. Contemporary pharmacotherapy and revascularization have improved the outcome and decreased the mortality rate of IHD, but effective therapies to reduce the progression of heart failure are limited. Cell therapy, a pivotal area in regenerative medicine, is gaining increasing attention within the scientific community. Transplanted cells may facilitate cardiac repair via paracrine effects and/or integration into the complex cell-cell communication network within the tissue microenvironment. The potential of various cell types to regenerate the injured heart has sparked new approaches and raised hope for more effective treatments. However, there are issues to be resolved in the field. The mechanisms underlying the benefits of cell therapy are not yet fully elucidated, and ideal regeneration therapeutic protocols involving cellular or molecular product manufacturing, delivery routes, and optimization of therapeutic effects have yet to be established.
In this Research Topic, we aim to create a forum for introducing and discussing the latest advances in cell therapy for IHD. This includes exploring a range of issues such as: cellular and molecular mechanisms linking cell therapy to cardiac repair and regeneration, novel cell types, cell engineering techniques, and cell transplantation modalities.
We welcome submissions on the following topics, but are not limited to:
- Mechanisms of cell and molecular products for cardiac repair and regeneration.
- Physiological cardiac regeneration in lower vertebrates and neonatal mammals.
- Advances in the design and manufacture of cell and molecular products for heart regeneration.
- Protocols for heart regenerative therapy.
- Analysis of the feasibility, safety, and effectiveness of new regenerative therapy in animal models and clinical trials.
- Biomarkers and predictive models for prognosis in regenerative therapies.
- The impact of organ crosstalk on cardiac health and regeneration.
- Lifestyle influences and risk actors in regenerative outcomes.
- Innovative techniques for in vivo cell tracing and cell fate control after transplantation
In this Research Topic, we aim to create a forum for introducing and discussing the latest advances in cell therapy for IHD. This includes exploring a range of issues such as: cellular and molecular mechanisms linking cell therapy to cardiac repair and regeneration, novel cell types, cell engineering techniques, and cell transplantation modalities.
We welcome submissions on the following topics, but are not limited to:
- Mechanisms of cell and molecular products for cardiac repair and regeneration.
- Physiological cardiac regeneration in lower vertebrates and neonatal mammals.
- Advances in the design and manufacture of cell and molecular products for heart regeneration.
- Protocols for heart regenerative therapy.
- Analysis of the feasibility, safety, and effectiveness of new regenerative therapy in animal models and clinical trials.
- Biomarkers and predictive models for prognosis in regenerative therapies.
- The impact of organ crosstalk on cardiac health and regeneration.
- Lifestyle influences and risk actors in regenerative outcomes.
- Innovative techniques for in vivo cell tracing and cell fate control after transplantation
Keywords: cell therapy, cardiac regeneration, ischemic heart disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
