About this Research Topic
Brain tumors pose significant treatment challenges due to their complex structure and the sensitive location within the brain. Surgical options are often limited by the brain's intricate layout, and systemic therapies are less effective due to the blood-tumor barrier (BTB) which is different from the standard blood-brain barrier (BBB). The surrounding environment of brain tumors includes a variety of cell types such as brain endothelial cells, astrocytes, neurons, and microglia, along with bone marrow-derived cells that migrate into the brain. This diversity adds to the complexity in treating brain cancers effectively.
The goal of this research is to fully understand the tumor environment in brain cancers to develop new treatment strategies. By studying how different cells within the environment interact and affect tumor growth and resistance, we can identify potential targets for therapy. This understanding could lead to breakthroughs in treatment options which are currently limited and not very effective.
This research issue welcomes contributions on the following topics:
•Comprehensive profiling of the diverse cellular make-up within the tumor environment.
•Investigating the roles of different brain and bone marrow-derived cells in tumor behavior. Contributions may expand to:
•Techniques to better visualize and analyze the tumor environment.
•New treatment methods that target specific cells within the tumor environment.
•The application of new technologies in delivering drugs effectively to the brain.
By focusing on these areas, the research aims to pave the way for developing targeted therapies that are crucial for improving the management and outcomes of brain cancer patients.
The goal of this research is to fully understand the tumor environment in brain cancers to develop new treatment strategies. By studying how different cells within the environment interact and affect tumor growth and resistance, we can identify potential targets for therapy. This understanding could lead to breakthroughs in treatment options which are currently limited and not very effective.
This research issue welcomes contributions on the following topics:
•Comprehensive profiling of the diverse cellular make-up within the tumor environment.
•Investigating the roles of different brain and bone marrow-derived cells in tumor behavior. Contributions may expand to:
•Techniques to better visualize and analyze the tumor environment.
•New treatment methods that target specific cells within the tumor environment.
•The application of new technologies in delivering drugs effectively to the brain.
By focusing on these areas, the research aims to pave the way for developing targeted therapies that are crucial for improving the management and outcomes of brain cancer patients.
Keywords: Brain Tumor Microenvironment (TME), Blood-Tumor Barrier (BTB), Therapeutic Targets, Molecular Characterization, Pre-clinical and Clinical Studies, Tumor Heterogeneity, Brain-Resident Cells, Bone Marrow-Derived Cells, Diagnostic Markers, Imaging Techniques
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
