Research has demonstrated that effective interventions at peripheral metabolic organs can significantly promote neuroplasticity, which is crucial for neurodevelopment, brain injury rehabilitation and mental health therapies. Clinical case studies have further illuminated the practical application of interventions at peripheral metabolic organs in the treatment of neurological disorders, offering a deeper understanding of their efficacy. Additionally, the impact of peripheral syndromes on neurological diseases, such as Pediatric epilepsy, Autistic Disorder (ASD), Attention Deficit and Hyperactivity Disorder (ADHD), and their underlying neuroplastic mechanisms have become an important focus, as they provide a new perspective on the pathophysiology and potential treatment strategies for these conditions. In summary, the investigation of central-peripheral interactions in neurodevelopment has opened up new avenues for understanding and addressing neurodevelopment and neurological diseases through innovative interventions that target the periphery to modulate central nervous system function.

In this topic, we aim to bring together cutting-edge researches on diverse aspects of neuroplasticity and development. We welcome authors to contribute works exploring molecular, cellular and systems level mechanisms of central-peripheral interactions in neurodevelopment and neuroplasticity, as well as the impact of developmental disorders and therapeutic interventions in this field. Here are questions of interest in our topic:

1. Effective interventions at peripheral metabolic organs to promote neuroplasticity in brain injury rehabilitation and mental health therapies.

2. Interactions between the central nervous system and peripheral systems in neuroplasticity.

3. Insights from clinical case studies into the practical application of interventions at peripheral metabolic organs in neurological disorders.

4. The impact of peripheral syndromes on neurological disease and underlying neuroplastic mechanisms.

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Frontiers in Molecular Neuroscience

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