In recent years, research has demonstrated that glycolipids and sphingolipids play a critical role in the differentiation and function of innate immune cells, including macrophages, neutrophils, and innate T cells. The ability of glycolipids from pathogenic microorganisms, such as Mycobacterium tuberculosis, to evade human phagocyte functions suggests that these immune cells can recognize and eliminate a broad range of pathogen-derived glycolipids. Glycolipids and sphingolipids also form clusters and microdomains called lipid rafts, which are enriched with cholesterol at the cell membrane surface. Numerous studies have shown that these rafts are crucial for regulating immune signaling and are involved in processes such as hemostasis and thrombosis. Furthermore, group 1 and group 2 CD1 molecules present glycolipids and sphingolipids to innate T cells, such as natural killer T (NKT) cells. These innate T cells bridge innate and adaptive immunity against pathogens, highlighting the importance of lipid-mediated immune responses. Glycolipids and sphingolipids play critical roles in regulating key functions like platelet activation and aggregation. Recent research has revealed that platelets are involved not only in hemostasis but also in innate immunity. For instance, platelets can bind to pathogens, neutralizing them, and engage with immune cells to enhance inflammatory responses.
This Research Topic collection aims to deepen our understanding of how glycolipids and sphingolipids influence the differentiation and functional regulation of blood cells involved in the innate immune response. It also explores the impact of pathogenic glycolipids on host invasion and their interaction with innate immunity. We welcome contributions from researchers in these fields, including both review articles and original research papers. Submissions should address:
1) The role of glycolipids and sphingolipids in innate immune cell differentiation and function,
2) The regulation and homeostasis of host innate immunity by these lipids, or
3) The effects of pathogenic glycolipids and sphingolipids on host-pathogen interactions.
In this Research Topic we welcome the submission of manuscripts that cover recent advances in the following areas:
• The role of glycolipids and sphingolipids in the differentiation and functions of blood cells involved in the innate immune response
• The regulation and homeostasis of host innate immunity by glycolipids and sphingolipids
• The effects of pathogenic glycolipids and sphingolipids on host-pathogen interactions
• The role of glycolipids and sphingolipids in regulating innate and cell-mediated immunity
Topic Editor Dr. Moriya Tsuji is a Scientific Advisor of Tinkeso Therapeutics. The other Topic Editors have no conflict of interest to declare.
Keywords:
glycolipids, sphingolipids, innate immunity, macrophages, neutrophils, lymphocytes, platelets, differentiation, pathogenic microorganisms, infection, immune response
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
In recent years, research has demonstrated that glycolipids and sphingolipids play a critical role in the differentiation and function of innate immune cells, including macrophages, neutrophils, and innate T cells. The ability of glycolipids from pathogenic microorganisms, such as Mycobacterium tuberculosis, to evade human phagocyte functions suggests that these immune cells can recognize and eliminate a broad range of pathogen-derived glycolipids. Glycolipids and sphingolipids also form clusters and microdomains called lipid rafts, which are enriched with cholesterol at the cell membrane surface. Numerous studies have shown that these rafts are crucial for regulating immune signaling and are involved in processes such as hemostasis and thrombosis. Furthermore, group 1 and group 2 CD1 molecules present glycolipids and sphingolipids to innate T cells, such as natural killer T (NKT) cells. These innate T cells bridge innate and adaptive immunity against pathogens, highlighting the importance of lipid-mediated immune responses. Glycolipids and sphingolipids play critical roles in regulating key functions like platelet activation and aggregation. Recent research has revealed that platelets are involved not only in hemostasis but also in innate immunity. For instance, platelets can bind to pathogens, neutralizing them, and engage with immune cells to enhance inflammatory responses.
This Research Topic collection aims to deepen our understanding of how glycolipids and sphingolipids influence the differentiation and functional regulation of blood cells involved in the innate immune response. It also explores the impact of pathogenic glycolipids on host invasion and their interaction with innate immunity. We welcome contributions from researchers in these fields, including both review articles and original research papers. Submissions should address:
1) The role of glycolipids and sphingolipids in innate immune cell differentiation and function,
2) The regulation and homeostasis of host innate immunity by these lipids, or
3) The effects of pathogenic glycolipids and sphingolipids on host-pathogen interactions.
In this Research Topic we welcome the submission of manuscripts that cover recent advances in the following areas:
• The role of glycolipids and sphingolipids in the differentiation and functions of blood cells involved in the innate immune response
• The regulation and homeostasis of host innate immunity by glycolipids and sphingolipids
• The effects of pathogenic glycolipids and sphingolipids on host-pathogen interactions
• The role of glycolipids and sphingolipids in regulating innate and cell-mediated immunity
Topic Editor Dr. Moriya Tsuji is a Scientific Advisor of Tinkeso Therapeutics. The other Topic Editors have no conflict of interest to declare.
Keywords:
glycolipids, sphingolipids, innate immunity, macrophages, neutrophils, lymphocytes, platelets, differentiation, pathogenic microorganisms, infection, immune response
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.