Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality worldwide. Despite significant advancements in medical treatments, preventive strategies focusing on natural compounds have garnered increasing attention. Among these, natural antioxidants have shown promising potential in mitigating oxidative stress, a key contributor to the pathogenesis of CVDs. This Research Topic, "Natural Antioxidants and Cardiovascular Diseases: A Pathway to Prevention," aims to explore the therapeutic potential and mechanistic insights of natural antioxidants in the prevention and management of cardiovascular diseases.

The scope of this Research Topic encompasses a wide range of interdisciplinary studies. We welcome original research articles, comprehensive reviews, clinical trials, perspective pieces, and meta-analyses that focus on the following areas but are not limited to:

- Mechanistic Studies: Investigations into the molecular mechanisms by which natural antioxidants can influence cardiovascular health. This includes the modulation of oxidative stress, inflammation, endothelial function, and lipid metabolism.
- Clinical Efficacy: Clinical trials and observational studies assessing the efficacy and safety of natural antioxidants in the prevention and treatment of various cardiovascular conditions, such as hypertension, atherosclerosis, myocardial infarction, and heart failure.
- Nutraceuticals and Functional Foods: Research on the role of antioxidant-rich foods and nutraceuticals in cardiovascular health. Potential topics include the impact of dietary patterns, specific antioxidant compounds, and bioavailability of these compounds in the human body.
- Pharmacology and Toxicology: Studies focusing on the pharmacokinetics, pharmacodynamics, and toxicological profiles of natural antioxidants. This includes dose-response relationships, potential drug interactions, and long-term safety assessments.
- Translational Research: Bridging the gap between laboratory findings and clinical practice. Studies that demonstrate the applicability of laboratory insights into real-world clinical scenarios, potentially leading to new preventive measures or therapeutic options for CVDs.

The overall aim of this Research Topic is to bring together cutting-edge research that advances our understanding of natural antioxidants as a preventive strategy against cardiovascular diseases. By fostering a multidisciplinary dialogue, we hope to spur innovation and facilitate the development of novel, nature-derived approaches to cardiovascular health.

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Frontiers in Cardiovascular Medicine

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