Osteoarthritis and osteoporosis are two common skeletal disorders that impose a significant burden on global health. Understanding the genetic and molecular basis of these diseases is crucial for the development of effective diagnostic tools, therapeutic strategies, and preventive measures. Recent advancements in genomics, proteomics, and epigenetics have provided valuable insights into the underlying mechanisms of osteoarthritis and osteoporosis. However, comprehensive and integrative research is still needed to bridge the knowledge gaps and translate these findings into clinical practice.

This Research Topic aims to bring together cutting-edge research in the field of genetic and molecular studies on osteoarthritis and osteoporosis, including GWAS, epigenetic modification, transcriptomics, proteomics, potential molecular mechanisms, and translational studies of genetic applications. We hope to facilitate the dissemination of new research findings and promote scientific exchange and collaboration among researchers in this field, identify research gaps and future directions for further exploration, guide the development of future research projects, and enhance the visibility and impact of the journal in the field of skeletal disorders research and attract high-quality submissions.

We seek to bring together Original Research, Reviews, Commentary articles, and Perspectives that focus on topics related to genetic and molecular research on osteoarthritis and osteoporosis, including but not limited to:
• Genome-wide association studies (GWAS) and candidate gene approaches to identify genetic variants associated with osteoarthritis and osteoporosis.
• Epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA regulation, in the development and progression of these diseases.
• Molecular mechanisms underlying bone remodeling and cartilage homeostasis, including the role of cytokines, growth factors, and signaling pathways.
• Genomic and proteomic profiling of osteoarthritis and osteoporosis tissues and cells to identify potential biomarkers for diagnosis and prognosis.
• Functional studies of identified genetic variants and molecular targets to elucidate their pathogenic roles.
• Translational research on the application of genetic and molecular findings in the development of novel therapeutic approaches and personalized medicine.

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Frontiers in Genetics

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