With the evolution of modern lifestyles and changes in environmental conditions, there has been a significant increase in immune-related health issues, such as autoimmune diseases, infectious diseases, fibrotic disorders, and cancer. Given the complexity of the causes of immune diseases, the treatment of these conditions has faced significant challenges. Understanding the mechanisms of disease progression, such as key signaling pathways and immune cell cross-talk, is crucial for effective treatment. Additionally, while some critical targets have been well identified, corresponding therapeutic drugs are still lacking. Leveraging advanced technologies for large-scale analysis of signaling pathways and disease models significantly accelerates the progress of drug discovery and development.
This research topic will focus on collecting studies related to pharmacological mechanisms and drug development based on advanced technologies. It includes analyses of immune disease-related signaling pathways, drug pharmacodynamics, and drug development by utilizing cutting-edge techniques such as single-cell sequencing and proteo-transcriptomics. The aim is to deepen our understanding and improve the design of therapeutic strategies for immune diseases.
We invite submissions of articles on the pathological mechanisms and drug development for immune diseases that incorporate advanced technologies. Topics of interest include, but are not limited to:
• New diagnostic and therapeutic approaches for immune diseases that target key biomarkers or critical molecular targets.
• Mechanisms of drug action explored through proteomics and transcriptomics research
• In-depth validation of disease targets beyond initial analysis, including signaling pathway and pharmacological analysis
• Development of novel anti-inflammatory agents, including anti-infective, anti-fibrotic agents
• Discovery of novel immuno-oncology drugs or adjuvant therapies for tumor immunotherapy
• Discovery of novel agents targeting purinergic receptors for immunotherapy
• Novel agents modulating cell-cell crosstalk for anti-inflammatory therapy
Please note that manuscripts focusing on network pharmacology using docking and bioinformatic network analysis will be considered only if they provide specific experimental evidence for a single pathway or molecular target. Moreover, the structure-activity relationship (SAR) between the ligand and the target needs to be well characterized.
Keywords:
Advanced diagnostics, immunological disease, biomarkers, autoimmune diseases, infectious diseases, fibrotic diseases, cancer therapy
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
With the evolution of modern lifestyles and changes in environmental conditions, there has been a significant increase in immune-related health issues, such as autoimmune diseases, infectious diseases, fibrotic disorders, and cancer. Given the complexity of the causes of immune diseases, the treatment of these conditions has faced significant challenges. Understanding the mechanisms of disease progression, such as key signaling pathways and immune cell cross-talk, is crucial for effective treatment. Additionally, while some critical targets have been well identified, corresponding therapeutic drugs are still lacking. Leveraging advanced technologies for large-scale analysis of signaling pathways and disease models significantly accelerates the progress of drug discovery and development.
This research topic will focus on collecting studies related to pharmacological mechanisms and drug development based on advanced technologies. It includes analyses of immune disease-related signaling pathways, drug pharmacodynamics, and drug development by utilizing cutting-edge techniques such as single-cell sequencing and proteo-transcriptomics. The aim is to deepen our understanding and improve the design of therapeutic strategies for immune diseases.
We invite submissions of articles on the pathological mechanisms and drug development for immune diseases that incorporate advanced technologies. Topics of interest include, but are not limited to:
• New diagnostic and therapeutic approaches for immune diseases that target key biomarkers or critical molecular targets.
• Mechanisms of drug action explored through proteomics and transcriptomics research
• In-depth validation of disease targets beyond initial analysis, including signaling pathway and pharmacological analysis
• Development of novel anti-inflammatory agents, including anti-infective, anti-fibrotic agents
• Discovery of novel immuno-oncology drugs or adjuvant therapies for tumor immunotherapy
• Discovery of novel agents targeting purinergic receptors for immunotherapy
• Novel agents modulating cell-cell crosstalk for anti-inflammatory therapy
Please note that manuscripts focusing on network pharmacology using docking and bioinformatic network analysis will be considered only if they provide specific experimental evidence for a single pathway or molecular target. Moreover, the structure-activity relationship (SAR) between the ligand and the target needs to be well characterized.
Keywords:
Advanced diagnostics, immunological disease, biomarkers, autoimmune diseases, infectious diseases, fibrotic diseases, cancer therapy
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.