Due to the remarkable success of the Research Topic 'Biomarkers of Health and Disease in Veterinary Science' and the rapidly evolving subject area, we are pleased to launch Volume II for this topic.

A biomarker is a characteristic objectively measured and evaluated as an indication of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. Suitable biomarkers should be measurable with little or no variability, should have a sizeable signal-to-noise ratio, and change promptly and reliably in response to changes in the condition or its therapy. The use of clinical biomarkers has the advantages of being simpler and less expensive to measure than final clinical endpoints. Also, they can be analysed repeatedly and over a shorter time. Biomarkers can be used as prognostic indicators in disease screening, diagnosis, characterization, and monitoring. The value of biomarkers in veterinary medicine has been increasing for decades, where different biomarkers have been discovered in dogs, cats, horses, and pigs, among others, as well as in diverse biological fluids (serum, saliva, urine, etc.). The application of these biomarkers has improved the diagnosis, treatment, and monitoring of pathologies in veterinary medicine.

Numerous studies try to identify new biomarkers for multiple diseases using biological fluids or tissues. There are various biomarker detection techniques that are capable of identifying a large battery of molecules that can become useful biomarkers, although they sometimes provide ambiguous and imprecise information on clinical application in different scenarios. The intention of this topic is to unite the studies dedicated to the identification and further validation of biomarkers in any veterinary species and to demonstrate their clinical application utility to prevent the progression of diseases and the search for new therapeutic strategies and approaches.

This Research Topic welcomes original research papers, review articles, and systematic reviews related to biomarkers of health and disease, including but not limited, to the following topics:

- Application of biomarkers in animal pathologies.
- Advances in the pathophysiology understanding of animal pathologies through the use of disease-specific biomarkers.
- Development of biomarkers using non-invasive sampling methods.
- Validation of biomarkers in automated assays.
- Method development and validation for biomarkers.
- Creation of diagnostic algorithms for animal pathologies using a comprehensive panel of biomarkers.
- The implication of circadian rhythm in the biomarker investigation and application.
- Comparative studies between different sources of biomarkers
- Biomarkers of stress.
- Biomarkers of septic and aseptic inflammation.
- Biomarkers of immune diseases.
- Development of biomarkers through the use of proteomics.
- Development of biomarkers through the use of metabolomics.
- Advantages and inconveniences of biomarkers.

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Frontiers in Veterinary Science

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