About this Research Topic
Cilia are antenna-like structures present in a variety of vertebrate cells. There are two broad classes of cilia, which are nonmotile (primary) and motile cilia. Cilia contain various machinery that detects signals from extracellular cues and transduce them into the cell to regulate and express the functions of the cells. The functions of cilia are spatiotemporally regulated, enabling cells to proliferate, migrate, and differentiate in a controlled manner. Dysregulation of cilia function can cause various diseases, including cancer, metabolic diseases, neurodevelopmental and neurodegenerative disorders. Dysregulation of cilia functions may be treated by genetic and/or pharmacological therapies targeting genes and signal transductions related to cilia.
The mechanisms underlying the cilia function in physiological and pathophysiological conditions have been extensively investigated. These studies have revealed many aspects of cilia, including genes involved in the formation and function, the signal transductions mediated by cilia, and the regulatory roles of cilia on other cellular components such as endosomes and lipid rafts. It has also been demonstrated that centrosomes move to the cell surface where the mother centrioles differentiate into basal bodies to nucleate cilia. These findings suggest that we can consider cilia and centrosomes as therapeutic targets.
The scope of this Research Topic is to integrate the current knowledge and opinions about primary and motile cilia and centrosomes as therapeutic targets. We are interested in original research, systematic review, methods, review, mini review, hypothesis and theory, perspective, and brief research report that fit within the scope of the research topic. Areas to be covered in this research topic may include, but are not limited to:
• Novel mechanisms underlying (patho)physiological functions of cilia and centrosomes
• Modulation of signal transductions through cilia and centrosomes
• Functional links between cilia, centrosomes, and other cellular components
• Animal models toward the development of novel therapies targeting cilia and centrosomes
• Novel tools and methods for analyzing cilia and centrosomes
• Therapeutic approaches targeting cilia and centrosomes
The mechanisms underlying the cilia function in physiological and pathophysiological conditions have been extensively investigated. These studies have revealed many aspects of cilia, including genes involved in the formation and function, the signal transductions mediated by cilia, and the regulatory roles of cilia on other cellular components such as endosomes and lipid rafts. It has also been demonstrated that centrosomes move to the cell surface where the mother centrioles differentiate into basal bodies to nucleate cilia. These findings suggest that we can consider cilia and centrosomes as therapeutic targets.
The scope of this Research Topic is to integrate the current knowledge and opinions about primary and motile cilia and centrosomes as therapeutic targets. We are interested in original research, systematic review, methods, review, mini review, hypothesis and theory, perspective, and brief research report that fit within the scope of the research topic. Areas to be covered in this research topic may include, but are not limited to:
• Novel mechanisms underlying (patho)physiological functions of cilia and centrosomes
• Modulation of signal transductions through cilia and centrosomes
• Functional links between cilia, centrosomes, and other cellular components
• Animal models toward the development of novel therapies targeting cilia and centrosomes
• Novel tools and methods for analyzing cilia and centrosomes
• Therapeutic approaches targeting cilia and centrosomes
Keywords: primary cilia, motile cilia, centrosome, cilia-related diseases, therapeutic target
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
