Macrophages play a pivotal role in the immune system and have several polarized subtypes. Type 1 (M1) and type 2 (M2) can respectively resist or help tumor growth in cancer for tumors and their microenvironment. progression. In particular, tumor-associated macrophages (TAMs) are similar to type M2 and can support tumor cells. However, macrophages also serve a regulatory role in several inflammation-related diseases. Interestingly, M2 type has an inhibitory effect on inflammation, significantly reducing inflammasome and improving inflammation-related systemic diseases, such as rheumatoid arthritis (RA), diabetes...etc. At present, macrophage polarization-related markers and functions are well known. However, the important mechanisms and applications still need to be understood in depth.
For macrophage polarization or monocyte induction. These well-known patterns can be studied using a variety of corresponding molecules. However, it is important to understand that during disease and tumor processes, transformations are not fixed but dynamic. Therefore, it is important to understand the detailed mechanisms of action, key regulatory factors and methods. In this Research Topic, we hope to 1). show that many approaches (physical, chemical, pharmaceutical, etc.) can control macrophage polarization, subtypes and corresponding phenotypes. 2). Explain which signaling pathways or networks are involved. More importantly, 3). It can be proposed to achieve anti-tumor/anti-inflammatory therapeutic effects by regulating macrophages. Our vision is to achieve therapeutic effects and translate medical value by regulating macrophages instead of discussing basic fields and theories.
This Research Topic welcomes basic/clinical researchers involved in cancer immunology and inflammatory diseases. All observations related to macrophage regulation and novelty will be considered. Submission types include original research, review, short communication, and case report. We encourage interdisciplinary and integrative research topics, but exclude only in silico analysis or omics integration reviews.
Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.
Keywords:
Macrophage, polarization, inflammation, cancer, applications
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Macrophages play a pivotal role in the immune system and have several polarized subtypes. Type 1 (M1) and type 2 (M2) can respectively resist or help tumor growth in cancer for tumors and their microenvironment. progression. In particular, tumor-associated macrophages (TAMs) are similar to type M2 and can support tumor cells. However, macrophages also serve a regulatory role in several inflammation-related diseases. Interestingly, M2 type has an inhibitory effect on inflammation, significantly reducing inflammasome and improving inflammation-related systemic diseases, such as rheumatoid arthritis (RA), diabetes...etc. At present, macrophage polarization-related markers and functions are well known. However, the important mechanisms and applications still need to be understood in depth.
For macrophage polarization or monocyte induction. These well-known patterns can be studied using a variety of corresponding molecules. However, it is important to understand that during disease and tumor processes, transformations are not fixed but dynamic. Therefore, it is important to understand the detailed mechanisms of action, key regulatory factors and methods. In this Research Topic, we hope to 1). show that many approaches (physical, chemical, pharmaceutical, etc.) can control macrophage polarization, subtypes and corresponding phenotypes. 2). Explain which signaling pathways or networks are involved. More importantly, 3). It can be proposed to achieve anti-tumor/anti-inflammatory therapeutic effects by regulating macrophages. Our vision is to achieve therapeutic effects and translate medical value by regulating macrophages instead of discussing basic fields and theories.
This Research Topic welcomes basic/clinical researchers involved in cancer immunology and inflammatory diseases. All observations related to macrophage regulation and novelty will be considered. Submission types include original research, review, short communication, and case report. We encourage interdisciplinary and integrative research topics, but exclude only in silico analysis or omics integration reviews.
Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic.
Keywords:
Macrophage, polarization, inflammation, cancer, applications
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.