About this Research Topic
Noncommunicable chronic diseases (NCDs) are the leading cause of death and disability worldwide, with cardiovascular disease, diabetes, obesity and cancer being the most prevalent. Despite the significant role of genetics, the rising mortality rates are largely influenced by environmental factors and lifestyle behaviors (i.e., diet, physical activity, environmental pollution, stress). Epidemiological evidence supports that a diet high in polyphenolic compounds is linked to a reduced risk of various NCDs, indicating that these bioactive compounds can prevent disease occurrence due to their anti-inflammatory and antioxidant activity. Studies have shown the potential of polyphenols to protect against oxidative stress and to inhibit pro-inflammatory transcription factors. Besides their antioxidant properties, polyphenols are also recognized for their capacity to modulate gene expression and induce epigenetic changes highlighting their crucial role in preventing or managing chronic diseases. Furthermore, modulation of the gut microbiota also plays an important role in the prevention of various NCDs. Recent evidence has shown that dietary polyphenols and their metabolites can alter the composition of gut microbiota (i.e., increase or decrease both beneficial and harmful microbial species), demonstrating their beneficial health effects.
This Research Topic aims to contribute to the knowledge around dietary polyphenols, by presenting current and novel research on the biological mechanisms at a cellular, molecular and metabolic level, underlying the effect of diverse phenolic compounds on NCD prevention and management. Understanding these mechanistic pathways, may serve as another avenue to promote health at a primary and secondary prevention level.
The Research Topic welcomes the submission of original research and reviews of published literature, exploring the effects of dietary polyphenols (and their metabolites) on NCD prevention, focused on
• examining associations between polyphenols and cardiometabolic risk factors and NCDs (observational studies); assessing the effect of polyphenols on risk factors and/or NCDs (experimental studies).
• nutritional interactions and precise mechanisms, especially those related to the generation of metabolites and/or their impact on gut microbiota composition; epigenetics modulation; and metabolic phenotyping.
Articles exploring innovative technological design of food products to prevent NCDs are also welcome.
This Research Topic aims to contribute to the knowledge around dietary polyphenols, by presenting current and novel research on the biological mechanisms at a cellular, molecular and metabolic level, underlying the effect of diverse phenolic compounds on NCD prevention and management. Understanding these mechanistic pathways, may serve as another avenue to promote health at a primary and secondary prevention level.
The Research Topic welcomes the submission of original research and reviews of published literature, exploring the effects of dietary polyphenols (and their metabolites) on NCD prevention, focused on
• examining associations between polyphenols and cardiometabolic risk factors and NCDs (observational studies); assessing the effect of polyphenols on risk factors and/or NCDs (experimental studies).
• nutritional interactions and precise mechanisms, especially those related to the generation of metabolites and/or their impact on gut microbiota composition; epigenetics modulation; and metabolic phenotyping.
Articles exploring innovative technological design of food products to prevent NCDs are also welcome.
Keywords: polyphenols; bioactive compounds; functional foods; bioavailability; noncommunicable chronic diseases; oxidative stress; inflammation; gut microbiota modulation; epigenetics.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
