Analysis of cellular and circuit activity with high spatiotemporal resolution is crucial to understanding brain function. Recently, emerging optical techniques opened a door to achieve this. For example, fluorescent probes for neurotransmitter, intracellular signaling and membrane potential, and optogenetic tools enabled researchers to measure and manipulate diverse functions of the neuronal cells and circuits. Multi-photon microscopy and improved endoscopy enabled analysis of neural circuit function in vivo. The development of optical techniques continues to progress aiming to further improve the signal-to-noise ratio of the fluorescent probes, enhance spatiotemporal resolution and expand the size of the field of view, and achieve new advances in neuroscience.
This research topic will present research or reviews of cutting-edge optical methods and their application to the development, functions and pathophysiology of the nervous system to showcase the current state-of-the-art technologies, and to explore the next generation technology and highlight novel applications of the methods.
We welcome original research, methods and review articles on optical methods or their physiological and pathophysiological applications both in vitro and in vivo. Subtopics include the following, but are not limited to:
- Development of fluorescent probes for neurotransmitters, ions, membrane potential, intracellular signaling
- Novel microscopy for ultrafast imaging or mesoscopic imaging
- Optical recording from freely moving animals
- Optical approaches to elucidate cellular or circuit functions in behaving animals
- Pathophysiological studies of neurological disorders using optical methods
Keywords:
imaging, optogenetics, fluorescent probes, optical methods, intracellular signaling, dendritic computation, neural circuits, development, neurological disorders
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Analysis of cellular and circuit activity with high spatiotemporal resolution is crucial to understanding brain function. Recently, emerging optical techniques opened a door to achieve this. For example, fluorescent probes for neurotransmitter, intracellular signaling and membrane potential, and optogenetic tools enabled researchers to measure and manipulate diverse functions of the neuronal cells and circuits. Multi-photon microscopy and improved endoscopy enabled analysis of neural circuit function in vivo. The development of optical techniques continues to progress aiming to further improve the signal-to-noise ratio of the fluorescent probes, enhance spatiotemporal resolution and expand the size of the field of view, and achieve new advances in neuroscience.
This research topic will present research or reviews of cutting-edge optical methods and their application to the development, functions and pathophysiology of the nervous system to showcase the current state-of-the-art technologies, and to explore the next generation technology and highlight novel applications of the methods.
We welcome original research, methods and review articles on optical methods or their physiological and pathophysiological applications both in vitro and in vivo. Subtopics include the following, but are not limited to:
- Development of fluorescent probes for neurotransmitters, ions, membrane potential, intracellular signaling
- Novel microscopy for ultrafast imaging or mesoscopic imaging
- Optical recording from freely moving animals
- Optical approaches to elucidate cellular or circuit functions in behaving animals
- Pathophysiological studies of neurological disorders using optical methods
Keywords:
imaging, optogenetics, fluorescent probes, optical methods, intracellular signaling, dendritic computation, neural circuits, development, neurological disorders
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.