The field of tumor clinical molecular biology has seen significant advancements with the integration of multi-disciplinary technologies, focusing on the molecular characteristics of malignant tumors. This area of research delves into genomics, transcriptomics, proteomics, and the microbiome to understand the complex nature of tumors. The rapid development of artificial intelligence and machine learning algorithms has further enriched this field, offering innovative approaches to explore and apply tumor molecular targets. Despite these advancements, there remain critical gaps in understanding the intricate processes of tumor occurrence, development, and metastasis, as well as their interactions with the host body. Current studies have provided insights into these areas, yet a comprehensive understanding that can translate into effective clinical applications is still lacking. Addressing these gaps is crucial for improving early diagnosis, prevention, and treatment strategies for malignant tumors.

This Research Topic aims to explore the clinical molecular biological characteristics of malignant tumors, with a focus on integrating clinical samples and data. The primary objectives include analyzing tumor-related molecular data, applying machine learning algorithms to clinical data, and validating molecular classifications and targeted therapies through clinical samples. Additionally, the research seeks to investigate the relationship between tumors and microbes through genome sequencing technology and to conduct immunoomics studies based on tumor genome sequencing. These efforts aim to bridge the gap between molecular research and clinical application, ultimately enhancing patient outcomes.

To gather further insights in the clinical molecular biological characteristics of malignant tumors, we welcome articles addressing, but not limited to, the following themes:
- Analysis of tumor-related molecular data from public databases.
- Clinical data analysis based on machine learning algorithms.
- Molecular classification of tumors and molecular targeted therapy, verified by clinical samples.
- Study on tumor microbiome based on genome sequencing technology to explore the relationship between tumors and microbes.
- Immunoomics study based on tumor genome sequencing technology.

Topic editor Wei Mingxing is employed by Cellvax. The other Topic Editors declare no potential conflicts of interest with regards to the Research Topic subject.

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Frontiers in Molecular Biosciences

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