About this Research Topic
Background
This Frontiers Research Topic is a collection of several papers presenting studies and reviews on the common theme, "The Sodium Pump and Cardiotonic Steroids in Health and Disease". Despite many controversies and periods of skepticism, the development of the “Concept of the Natriuretic Hormone” as a third factor in the pathogenesis of hypertension, cardiotonic steroidal sodium pump ligands not only fulfilled the initial intuition of deWardener, Blaustein, Buckalew, and other scientists, creating this Concept, but substantially exceeded it. Regarding cardiotonic steroids (CS) per se, it is becoming clear that there are several steroidal endogenous factors that are interacting with each other on multiple biochemical levels in a complex manner and are accounting for the effects of the putative natriuretic hormone.
Goal
Recent studies demonstrated that cardenolides, i.e., ouabain, digoxin, etc., and bufadienolides, including marinobufagenin, bufalin, telocinobufagin, etc., regulate tissue growth, apoptosis, and immune and inflammation responses. Thus, CS functions include not only the inhibition of Na+/K+-ATPase, and the regulation of the monovalent ions balance and cell homeostasis, but also the initiation of multi-signaling cascade transduction pathways, whose components are promising targets for the development of more personalized and specific drugs. Dysregulation of CS and its association with Na+/K+-ATPase plays an important role in multiple diseases, including chronic kidney disease, cancers, preeclampsia, hypertension, and other disorders. The last decade was marked by the multiple exciting papers on CS involvement in oncological events, tissue growth and neurological disfunctions. Thus, the roles of natriuretic hormones go far beyond the regulation of fluid volume, natriuresis, and vascular tone.
Scope and information for authors
The editors of this Frontiers Research Topic believe that this is an appropriate time for compiling the studies in the field of investigation of Na+/K+-ATPase and its endogenous steroidal inhibitors and ligands that has radically altered and enhanced our understanding of the nature of CS. The present issue is dedicated to the recent findings related to the multifaceted role of these incredible molecules in health and disease. Authors are encouraged to submit their contributions through Frontiers in Physiology or Frontiers in Pharmacology.
We welcome original research, review, mini-review, and perspective articles on topics including, but not limited to:
Na/K-ATPase in disease and cellular functions
- Their role in cell adhesion and migration in cancer
- Na/K-ATPase as a modulator of apoptosis and autophagy
- Na/K-ATPase signaling in bipolar disorder
Cardiotonic steroids and signal transduction
- Their effect on Na/K-ATPase-mediated signal transduction
- Their role as endogenous regulators in the nervous system
- Ouabain and cell-cell adhesion mediated by the N/K-ATPase
- Ouabain and cell migration through a cSrc and ERK1/2
- Bufadienolides in cancer treatment
Cardiotonic steroids in hypertension and renal diseases
- CSs in hypertension pathophysiology and treatment
- Endogenous ouabain and related genes in the translation from hypertension to renal diseases
- CSs in preeclampsia
- Endogenous bufadienolides and aldosterone antagonists in fibrosis and chronic kidney disease
Cardiotonic steroids and other health conditions
- Impact on aging
- Oxidative stress regulation
- Role in obesity
- Vascular remodeling and cognitive impairment with marinobufagenin
- Contribution of endogenous Na/K-ATPase inhibitors and cerebrospinal fluid [Na+] to migraine formation
- Antiviral properties for emerging coronavirus infections
- Natriuretic and vasoconstriction functions
Cardiotonic steroid biosynthesis and drug development
Topic Editor Dr. Alexei Bagrov is a principal investigator at Padakonn Pharma, Narva, Estonia. He also holds a patent related to the antibodies to marinobufagenin and their use. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
This Frontiers Research Topic is a collection of several papers presenting studies and reviews on the common theme, "The Sodium Pump and Cardiotonic Steroids in Health and Disease". Despite many controversies and periods of skepticism, the development of the “Concept of the Natriuretic Hormone” as a third factor in the pathogenesis of hypertension, cardiotonic steroidal sodium pump ligands not only fulfilled the initial intuition of deWardener, Blaustein, Buckalew, and other scientists, creating this Concept, but substantially exceeded it. Regarding cardiotonic steroids (CS) per se, it is becoming clear that there are several steroidal endogenous factors that are interacting with each other on multiple biochemical levels in a complex manner and are accounting for the effects of the putative natriuretic hormone.
Goal
Recent studies demonstrated that cardenolides, i.e., ouabain, digoxin, etc., and bufadienolides, including marinobufagenin, bufalin, telocinobufagin, etc., regulate tissue growth, apoptosis, and immune and inflammation responses. Thus, CS functions include not only the inhibition of Na+/K+-ATPase, and the regulation of the monovalent ions balance and cell homeostasis, but also the initiation of multi-signaling cascade transduction pathways, whose components are promising targets for the development of more personalized and specific drugs. Dysregulation of CS and its association with Na+/K+-ATPase plays an important role in multiple diseases, including chronic kidney disease, cancers, preeclampsia, hypertension, and other disorders. The last decade was marked by the multiple exciting papers on CS involvement in oncological events, tissue growth and neurological disfunctions. Thus, the roles of natriuretic hormones go far beyond the regulation of fluid volume, natriuresis, and vascular tone.
Scope and information for authors
The editors of this Frontiers Research Topic believe that this is an appropriate time for compiling the studies in the field of investigation of Na+/K+-ATPase and its endogenous steroidal inhibitors and ligands that has radically altered and enhanced our understanding of the nature of CS. The present issue is dedicated to the recent findings related to the multifaceted role of these incredible molecules in health and disease. Authors are encouraged to submit their contributions through Frontiers in Physiology or Frontiers in Pharmacology.
We welcome original research, review, mini-review, and perspective articles on topics including, but not limited to:
Na/K-ATPase in disease and cellular functions
- Their role in cell adhesion and migration in cancer
- Na/K-ATPase as a modulator of apoptosis and autophagy
- Na/K-ATPase signaling in bipolar disorder
Cardiotonic steroids and signal transduction
- Their effect on Na/K-ATPase-mediated signal transduction
- Their role as endogenous regulators in the nervous system
- Ouabain and cell-cell adhesion mediated by the N/K-ATPase
- Ouabain and cell migration through a cSrc and ERK1/2
- Bufadienolides in cancer treatment
Cardiotonic steroids in hypertension and renal diseases
- CSs in hypertension pathophysiology and treatment
- Endogenous ouabain and related genes in the translation from hypertension to renal diseases
- CSs in preeclampsia
- Endogenous bufadienolides and aldosterone antagonists in fibrosis and chronic kidney disease
Cardiotonic steroids and other health conditions
- Impact on aging
- Oxidative stress regulation
- Role in obesity
- Vascular remodeling and cognitive impairment with marinobufagenin
- Contribution of endogenous Na/K-ATPase inhibitors and cerebrospinal fluid [Na+] to migraine formation
- Antiviral properties for emerging coronavirus infections
- Natriuretic and vasoconstriction functions
Cardiotonic steroid biosynthesis and drug development
Topic Editor Dr. Alexei Bagrov is a principal investigator at Padakonn Pharma, Narva, Estonia. He also holds a patent related to the antibodies to marinobufagenin and their use. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: Na/K-ATPase, cardiotonic steroids, bufadienolides, cardenolides, biosynthesis, chronic kidney diseases, NaCl-sensitivity, neoplasms / drug therapy, Alzheimer's disease, hypertension
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
